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208293 Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01 - Calbiochem

208293
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개요

Replacement Information

주요 사양표

Empirical Formula
C₁₈H₂₁NO₄S

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208293-10MGCN
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      Glass bottle 10 mg
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      Description
      OverviewAn aminothiophene that inhibits Calcium-activated Chloride Channel (CaCC) current influx induced by multiple calcium-elevating agonists (IC50 = 10 µM) without inhibiting calcium elevation, and CaMKII and CFTR activity. Inhibits CaCC chloride response following agonist stimulation in human bronchial and intestinal epithelial cells. Also demonstrates an inhibitory effect on TMEM16A channels (IC50 = 2.1 µM). Also available as a 100 mM solution in DMSO (Cat. No. 508628).
      Catalogue Number208293
      Brand Family Calbiochem®
      SynonymsANO Blocker I, Anoctamin Blocker I, TMEM16 Blocker I, 6-tert-butyl-2-(furan-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid, CaCC Blocker I
      References
      ReferencesFuente, R., et al. 2011, Mol Pharmacol. 73, 758.
      Namkung, W., et al. 2011, J Biol Chem. 286, 2365.
      Product Information
      FormOff-white solid
      Hill FormulaC₁₈H₂₁NO₄S
      Chemical formulaC₁₈H₂₁NO₄S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01 - Calbiochem MSDS

      타이틀

      물질안전보건자료(MSDS) 

      Calcium-activated Chloride Channel Inhibitor, CaCCinh-A01 - Calbiochem Certificates of Analysis

      TitleLot Number
      208293

      References

      참고문헌 보기
      Fuente, R., et al. 2011, Mol Pharmacol. 73, 758.
      Namkung, W., et al. 2011, J Biol Chem. 286, 2365.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-May-2012 JSW
      SynonymsANO Blocker I, Anoctamin Blocker I, TMEM16 Blocker I, 6-tert-butyl-2-(furan-2-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid, CaCC Blocker I
      DescriptionAn aminothiophene that inhibits Calcium-activated Chloride Channel (CaCC) current influx induced by multiple calcium-elevating agonists (IC50 = 10 µM) without inhibiting calcium elevation, and CaMKII and CFTR activity. Inhibits CaCC chloride response following agonist stimulation in human bronchial and intestinal epithelial cells. Also demonstrates an inhibitory effect on TMEM16A channels (IC50 = 2.1 µM).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₈H₂₁NO₄S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml; pale yellow solution)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesFuente, R., et al. 2011, Mol Pharmacol. 73, 758.
      Namkung, W., et al. 2011, J Biol Chem. 286, 2365.