208748 Calpain-1 Substrate, Fluorogenic - Calbiochem

208748
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      208748-2MGCN
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          Plastic ampoule 2 mg
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          Description
          OverviewAn internally quenched fluorogenic substrate peptide derived from the calpain-1 cleavage site of α-spectrin. It is not recognized by trypsin or α-chymotrypsin and serves as a sensitive and specific substrate for calpain-1 (Km = 4.6 µM; kcat = 11 s-1). Cleavage occurs between Tyr-Gly residues and results in enhanced fluorescence.
          Catalogue Number208748
          Brand Family Calbiochem®
          Synonymsμ-Calpain Substrate, Fluorogenic, H-K(FAM)-EVY~GMMK(DABCYL)-OH
          References
          ReferencesMittoo, S., et al. 2003. Anal. Biochem. 319, 234.
          Product Information
          ATP CompetitiveN
          FormRed lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₇₉H₉₅N₁₃O₁₉S₂
          Chemical formulaC₇₉H₉₅N₁₃O₁₉S₂
          Hygroscopic Hygroscopic
          ReversibleN
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetA sensitive and specific substrate for calpain-1
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Emission max.
          Excitation max.
          Peptide SequenceH-Lys(FAM)-Glu-Val-Tyr~Gly-Met-Met-Lys(DABCYL)-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Calpain-1 Substrate, Fluorogenic - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Calpain-1 Substrate, Fluorogenic - Calbiochem Certificates of Analysis

          TitleLot Number
          208748

          References

          참고문헌 보기
          Mittoo, S., et al. 2003. Anal. Biochem. 319, 234.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-May-2008 RFH
          Synonymsμ-Calpain Substrate, Fluorogenic, H-K(FAM)-EVY~GMMK(DABCYL)-OH
          DescriptionAn internally quenched fluorogenic substrate peptide derived from the calpain-1 cleavage site of α-spectrin. It is not recognized by trypsin or α-chymotrypsin and serves as a sensitive and specific substrate for calpain-1 (Km = 4.6 µM; kcat = 11 s-1). Cleavage occurs at the Tyr-Gly bond and results in enhanced fluorescence. Excitation max: ~490 nm; emission max: ~518 nm.
          FormRed lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Recommended reaction conditions50 mM Tris-HCl, 50 mM NaCl, 5 mM β-mercaptoethanol, 5 mM CaCl2, 1 mM EDTA, 1 mM EGTA, and 1 µM substrate, pH 7.5.
          Chemical formulaC₇₉H₉₅N₁₃O₁₉S₂
          Peptide SequenceH-Lys(FAM)-Glu-Val-Tyr~Gly-Met-Met-Lys(DABCYL)-OH
          Purity≥95% by HPLC
          SolubilityDMSO (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesMittoo, S., et al. 2003. Anal. Biochem. 319, 234.