208743 Calpain Inhibitor XI - CAS 145731-49-3 - Calbiochem

208743
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      개요

      Replacement Information

      주요 사양표

      Empirical FormulaCAS #
      C₂₆H₄₀N₄O₆ 145731-49-3

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      208743-1MGCN
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          Plastic ampoule 1 mg
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          208743-5MGCN
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              Plastic ampoule 5 mg
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              Description
              OverviewA cell-permeable dipeptidyl α-ketoamide that acts as a potent, highly selective, reversible, and active site inhibitor of calpain-1 and -2 (Ki = 140 nM and 41 nM, respectively). Weakly inhibits cathepsin B (Ki = 6.9 µM). Reported to have a neuroprotective role in the central nervous system following focal ischemia. Also protects against virus-induced apoptotic myocardial injury in mice.
              Catalogue Number208743
              Brand Family Calbiochem®
              SynonymsZ-L-Abu-CONH(CH₂)₃-morpholine
              References
              ReferencesBlomgren, K., et al. 2001. J. Biol. Chem. 276, 10191.
              DeBiasi, R.L., et al. 2001. J. Virol. 75, 351.
              Saatman, K.E., et al. 2000. J. Cereb. Blood Flow Metab. 20, 66.
              Stelmasiak, Z., et al. 2000. Med. Sci. Monit. 6, 426.
              Blomgren, K., et al. 1999. J. Biol. Chem. 274, 14046.
              James, T., et al. 1998. J. Neurosci. Res. 51, 218.
              Li, Z., et al. 1996. J. Med. Chem. 39, 4089.
              Saatman, K.E, et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3428.
              Bartus, R.T., et al. 1995. Neurol. Res. 17, 249.
              Bartus, R.T., et al. 1994. Stroke 25, 2265.
              Product Information
              CAS number145731-49-3
              ATP CompetitiveN
              FormWhite to off-white solid
              FormulationSupplied as a trifluoroacetate salt.
              Hill FormulaC₂₆H₄₀N₄O₆
              Chemical formulaC₂₆H₄₀N₄O₆
              Hygroscopic Hygroscopic
              ReversibleY
              Structure formula ImageStructure formula Image
              Quality LevelMQ100
              Applications
              Biological Information
              Primary Targetcalpain 1, calpain 2
              Primary Target K<sub>i</sub>140 nM and 41 nM, against calpain-1 and -2, respectively
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableY
              Peptide SequenceZ-Leu-Abu-CONH(CH₂)₃-morpholine (Abu = α-aminobutyric acid)
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage +2°C to +8°C
              Hygroscopic Hygroscopic
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              Calpain Inhibitor XI - CAS 145731-49-3 - Calbiochem MSDS

              타이틀

              물질안전보건자료(MSDS) 

              Calpain Inhibitor XI - CAS 145731-49-3 - Calbiochem Certificates of Analysis

              TitleLot Number
              208743

              References

              참고문헌 보기
              Blomgren, K., et al. 2001. J. Biol. Chem. 276, 10191.
              DeBiasi, R.L., et al. 2001. J. Virol. 75, 351.
              Saatman, K.E., et al. 2000. J. Cereb. Blood Flow Metab. 20, 66.
              Stelmasiak, Z., et al. 2000. Med. Sci. Monit. 6, 426.
              Blomgren, K., et al. 1999. J. Biol. Chem. 274, 14046.
              James, T., et al. 1998. J. Neurosci. Res. 51, 218.
              Li, Z., et al. 1996. J. Med. Chem. 39, 4089.
              Saatman, K.E, et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3428.
              Bartus, R.T., et al. 1995. Neurol. Res. 17, 249.
              Bartus, R.T., et al. 1994. Stroke 25, 2265.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision04-May-2011 JSW
              SynonymsZ-L-Abu-CONH(CH₂)₃-morpholine
              DescriptionA cell-permeable dipeptidyl a-ketoamide that acts as a potent, highly selective, reversible, active site inhibitor of calpain-1 (Ki = 140 nM) and calpain-2 (Ki = 41 nM). Weakly inhibits cathepsin B (Ki = 6.9 µM). Shown to inhibit calpain-m-mediated degradation of neurofilament protein (NFP) (IC50 = 600 nM). Also shown to exhibit neuroprotective effects in the central nervous system following focal ischemia. Reported to protect against reovirus-induced myocarditis in mice.
              FormWhite to off-white solid
              FormulationSupplied as a trifluoroacetate salt.
              Intert gas (Yes/No) Packaged under inert gas
              CAS number145731-49-3
              Chemical formulaC₂₆H₄₀N₄O₆
              Peptide SequenceZ-Leu-Abu-CONH(CH₂)₃-morpholine (Abu = α-aminobutyric acid)
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityDMSO (5 mg/ml)
              Storage +2°C to +8°C
              Hygroscopic
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Standard Handling
              ReferencesBlomgren, K., et al. 2001. J. Biol. Chem. 276, 10191.
              DeBiasi, R.L., et al. 2001. J. Virol. 75, 351.
              Saatman, K.E., et al. 2000. J. Cereb. Blood Flow Metab. 20, 66.
              Stelmasiak, Z., et al. 2000. Med. Sci. Monit. 6, 426.
              Blomgren, K., et al. 1999. J. Biol. Chem. 274, 14046.
              James, T., et al. 1998. J. Neurosci. Res. 51, 218.
              Li, Z., et al. 1996. J. Med. Chem. 39, 4089.
              Saatman, K.E, et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3428.
              Bartus, R.T., et al. 1995. Neurol. Res. 17, 249.
              Bartus, R.T., et al. 1994. Stroke 25, 2265.