208925 Camptothecin, Camptotheca acuminata - CAS 2114454 - Calbiochem

208925
가격을 검색할 수 없습니다
Minimum Quantity needs to be mulitiple of
가격 문의 추가 정보
()이 할인됨
 
가격 문의
재고 없음재고 없음
예상 출고 가능일 
단종품
제한된 수량 가능
재고여부 확인
    Remaining: will advise
      Remaining: will advise
      추천사항
      고객 서비스로 문의
      Contact Customer Service
      가격 및 재고 조회

      개요

      Replacement Information

      주요 사양표

      Empirical FormulaCAS #
      C₂₀H₁₆N₂O₄ 7689-03-4

      가격 및 재고여부

      카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
      208925-50MGCN
      재고 정보 검색...
      재고 없음재고 없음
      예상 출고 가능일 
      단종품
      제한된 수량 가능
      재고여부 확인
        Remaining: will advise
          Remaining: will advise
          추천사항
          고객 서비스로 문의
          Contact Customer Service

          Alu drum 50 mg
          가격 검색...
          가격을 검색할 수 없습니다
          Minimum Quantity needs to be mulitiple of
          가격 문의 추가 정보
          ()이 할인됨
           
          가격 문의
          Description
          OverviewA cell-permeable DNA topoisomerase I inhibitor. Exhibits anti-leukemic and antitumor properties. Induces apoptosis in HL-60 cells and mouse thymocytes. Arrests cells at the G2/M phase.
          Catalogue Number208925
          Brand Family Calbiochem®
          Synonyms4-Ethyl-4-hydroxy-1H-pyrano[3ʹ,4ʹ:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione
          References
          ReferencesJones, C.B., et al. 1997. Cancer Chemother. Pharmacol. 40, 475.
          Staron, K., et al. 1994. Carcinogenesis 15, 2953.
          Tanizawa, A., et al. 1994. J. Natl. Cancer Inst. 86, 836.
          Gorczyca, W., et al. 1993. Toxicol. Lett. 67, 249.
          Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
          Pantazis, P., et al. 1993. Int. J. Cancer 53, 863.
          Morham, S.G., and Shuman, S. 1992. J. Biol. Chem. 267, 15984.
          Hertzberg, R.P., et al. 1990. Biochem. J. 28, 4629.
          Hertzberg, R.P., et al. 1990. J. Biol. Chem. 265, 19287.
          Hsiang, Y.H., et al. 1985. J. Biol. Chem. 260, 14873.
          Product Information
          CAS number7689-03-4
          ATP CompetitiveN
          FormPale yellow solid
          Hill FormulaC₂₀H₁₆N₂O₄
          Chemical formulaC₂₀H₁₆N₂O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetDNA topoisomerase 1
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSUQ0492000
          Safety Information
          R PhraseR: 25-36/37/38-46

          Toxic if swallowed.
          Irritating to eyes, respiratory system and skin.
          May cause heritable genetic damage.
          S PhraseS: 22-26-36/37/39-45

          Do not breathe dust.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Camptothecin, Camptotheca acuminata - CAS 2114454 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Camptothecin, Camptotheca acuminata - CAS 2114454 - Calbiochem Certificates of Analysis

          TitleLot Number
          208925

          References

          참고문헌 보기
          Jones, C.B., et al. 1997. Cancer Chemother. Pharmacol. 40, 475.
          Staron, K., et al. 1994. Carcinogenesis 15, 2953.
          Tanizawa, A., et al. 1994. J. Natl. Cancer Inst. 86, 836.
          Gorczyca, W., et al. 1993. Toxicol. Lett. 67, 249.
          Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
          Pantazis, P., et al. 1993. Int. J. Cancer 53, 863.
          Morham, S.G., and Shuman, S. 1992. J. Biol. Chem. 267, 15984.
          Hertzberg, R.P., et al. 1990. Biochem. J. 28, 4629.
          Hertzberg, R.P., et al. 1990. J. Biol. Chem. 265, 19287.
          Hsiang, Y.H., et al. 1985. J. Biol. Chem. 260, 14873.

          Brochure

          Title
          Caspases and other Apoptosis Related Tools Brochure
          Tools and Tips for Analyzing Apoptosis
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-July-2009 RFH
          Synonyms4-Ethyl-4-hydroxy-1H-pyrano[3ʹ,4ʹ:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione
          DescriptionA cell-permeable, reversible DNA topoisomerase I inhibitor that binds to and stabilizes the topoisomerase-DNA covalent complex. Possesses antileukemic and antitumor properties. Inhibits Tat-mediated transactivation of HIV-1. Cytostatic for non-tumorigenic cells but cytotoxic for tumorigenic cells. Induces apoptosis of HL-60 cells and mouse thymocytes.
          FormPale yellow solid
          CAS number7689-03-4
          RTECSUQ0492000
          Chemical formulaC₂₀H₁₆N₂O₄
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml) and MeOH (40 mg/ml). Stock solutions made with methanol will remain cloudy.
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Toxic & Carcinogenic / Teratogenic
          Merck USA index14, 1735
          ReferencesJones, C.B., et al. 1997. Cancer Chemother. Pharmacol. 40, 475.
          Staron, K., et al. 1994. Carcinogenesis 15, 2953.
          Tanizawa, A., et al. 1994. J. Natl. Cancer Inst. 86, 836.
          Gorczyca, W., et al. 1993. Toxicol. Lett. 67, 249.
          Onishi, Y., et al. 1993. Biochim. Biophys. Acta 1175, 147.
          Pantazis, P., et al. 1993. Int. J. Cancer 53, 863.
          Morham, S.G., and Shuman, S. 1992. J. Biol. Chem. 267, 15984.
          Hertzberg, R.P., et al. 1990. Biochem. J. 28, 4629.
          Hertzberg, R.P., et al. 1990. J. Biol. Chem. 265, 19287.
          Hsiang, Y.H., et al. 1985. J. Biol. Chem. 260, 14873.