212385 Carbachol - CAS 51-83-2 - Calbiochem

212385
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      개요

      Replacement Information

      주요 사양표

      Empirical FormulaCAS #
      C₆H₁₅ClN₂O₂ 51-83-2

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      212385-100MGCN
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          Alu drum 100 mg
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          Description
          OverviewAn unsubstituted carbamoyl ester that acts as an agonist for nicotinic and muscarinic acetylcholine receptors. Carbachol is totally resistant to the action of acetylcholine esterase (AChE) and non-specific cholinesterases. Inhibits apoptotic death of cultured granule neurons.
          Catalogue Number212385
          Brand Family Calbiochem®
          SynonymsCarbamoylcholine Chloride
          References
          ReferencesJence, M., et al. 1995. J. Neurochem. 64, 1605.
          Yan, G.M., et al. 1995. Mol. Pharmacol. 47, 248.
          Mangels, L.A., and Gnegy, M.E. 1992. J. Biol. Chem. 267, 5847.
          Watanabe, A.M., et al. 1992. In Basic and Clinical Pharmacology, Fifth Edition Katzung, B.G. ed.) Appleton and Lange, Norwalk, CT, p. 82.
          Howe, P.H., et al. 1986. J. Pharmacol. Exp. Ther. 239, 574.
          Product Information
          CAS number51-83-2
          ATP CompetitiveN
          FormWhite fine crystalline solid
          Hill FormulaC₆H₁₅ClN₂O₂
          Chemical formulaC₆H₁₅ClN₂O₂
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetAgonist for nicotinic and muscarinic acetylcholine receptors
          Purity≥99% by titration
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSGA0875000
          Safety Information
          R PhraseR: 26/27/28-36/37/38

          Very toxic by inhalation, in contact with skin and if swallowed.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 22-36/37/39-45

          Do not breathe dust.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +15°C to +30°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Carbachol - CAS 51-83-2 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Carbachol - CAS 51-83-2 - Calbiochem Certificates of Analysis

          TitleLot Number
          212385

          References

          참고문헌 보기
          Jence, M., et al. 1995. J. Neurochem. 64, 1605.
          Yan, G.M., et al. 1995. Mol. Pharmacol. 47, 248.
          Mangels, L.A., and Gnegy, M.E. 1992. J. Biol. Chem. 267, 5847.
          Watanabe, A.M., et al. 1992. In Basic and Clinical Pharmacology, Fifth Edition Katzung, B.G. ed.) Appleton and Lange, Norwalk, CT, p. 82.
          Howe, P.H., et al. 1986. J. Pharmacol. Exp. Ther. 239, 574.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-April-2008 RFH
          SynonymsCarbamoylcholine Chloride
          DescriptionAn unsubstituted carbamoyl ester that acts as an agonist for nicotinic and muscarinic acetylcholine receptors. Known to increase cytosolic Ca2+ and InsP3 and decrease cAMP levels. Resistant to the action of acetylcholine esterase (AChE) and non-specific cholinesterases. Inhibits apoptotic death of cultured granule neurons.
          FormWhite fine crystalline solid
          CAS number51-83-2
          RTECSGA0875000
          Chemical formulaC₆H₁₅ClN₂O₂
          Structure formulaStructure formula
          Purity≥99% by titration
          SolubilityH₂O (100 mg/ml), Ethanol (20 mg/ml), and Methanol(100 mg/ml)
          Storage +15°C to +30°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
          Toxicity Highly Toxic
          Merck USA index14, 1779
          ReferencesJence, M., et al. 1995. J. Neurochem. 64, 1605.
          Yan, G.M., et al. 1995. Mol. Pharmacol. 47, 248.
          Mangels, L.A., and Gnegy, M.E. 1992. J. Biol. Chem. 267, 5847.
          Watanabe, A.M., et al. 1992. In Basic and Clinical Pharmacology, Fifth Edition Katzung, B.G. ed.) Appleton and Lange, Norwalk, CT, p. 82.
          Howe, P.H., et al. 1986. J. Pharmacol. Exp. Ther. 239, 574.