218710 Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem

218710
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      개요

      Replacement Information

      주요 사양표

      Empirical FormulaCAS #
      C₉H₄Br₄O₂ 934358-00-6

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      218710-5MGCN
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          Plastic Bag(s) 5 mg
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          Description
          OverviewA cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM) with greater selectivity than TBB (Cat. Nos. 218697 and 218708) and DMAT (Cat. Nos. 218699 and 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induces apoptosis in Jurkat cells (DC50 = 7.7 µM). Also available as a 25 mM solution in DMSO (Cat. No. 218861).
          Catalogue Number218710
          Brand Family Calbiochem®
          Synonyms(E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid, CKII Inhibitor, TBCA
          References
          ReferencesPagano, M.A., et al. 2006. Chembiochem 8, 129
          Product Information
          CAS number934358-00-6
          ATP CompetitiveY
          FormOff-white solid
          Hill FormulaC₉H₄Br₄O₂
          Chemical formulaC₉H₄Br₄O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationCasein Kinase II Inhibitor III, TBCA, CAS 934358-00-6, is a cell-permeable, potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM).
          Biological Information
          Primary TargetCasein Kinase II
          Primary Target IC<sub>50</sub>110 nM
          Primary Target K<sub>i</sub>77 nM against Casein Kinase II
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem Certificates of Analysis

          TitleLot Number
          218710

          References

          참고문헌 보기
          Pagano, M.A., et al. 2006. Chembiochem 8, 129
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-April-2008 RFH
          Synonyms(E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid, CKII Inhibitor, TBCA
          DescriptionA cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM) with greater selectivity than TBB (Cat. Nos. 218697 and 218708) and DMAT (Cat. Nos. 218699 and 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induces apoptosis in Jurkat cells (DC50 = 7.7 µM).
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number934358-00-6
          Chemical formulaC₉H₄Br₄O₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml). Use only fresh DMSO.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          ReferencesPagano, M.A., et al. 2006. Chembiochem 8, 129