218718 Casein Kinase II Inhibitor VI, TMCB - CAS 905105-89-7 - Calbiochem

218718
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      개요

      Replacement Information

      주요 사양표

      Empirical FormulaCAS #
      C₁₁H₉Br₄N₃O₂ 905105-89-7

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      218718-10MGCN
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable tertabromobenzimidazolo TBB (Cat. Nos. 218699 and 218708) analog that acts as a highly selective (IC50 >10 µM against 71 other kinases) ATP-competitive inhibitor against CK2 (IC50 = 500 nM; Ki = 250 nM) and ERK8 (IC50 = 500 nM). K66 is reported to be more selective than either TBB or DMAT and selective CK2 inhibition by K66 is shown to be cytotoxic to non-ERK8-expressing Jurkat cells.
          Catalogue Number218718
          Brand Family Calbiochem®
          SynonymsERK8 Inhibitor I, 4,5,6,7-Tetrabromo-2-dimethylamino-1-carboxymethyl-benzimidazole, K66, Erk Inhibitor VI
          References
          ReferencesPagano, M.A., et al. 2008. Biochem. J. 415, 353.
          Product Information
          CAS number905105-89-7
          FormWhite powder
          Hill FormulaC₁₁H₉Br₄N₃O₂
          Chemical formulaC₁₁H₉Br₄N₃O₂
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Casein Kinase II Inhibitor VI, TMCB - CAS 905105-89-7 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Casein Kinase II Inhibitor VI, TMCB - CAS 905105-89-7 - Calbiochem Certificates of Analysis

          TitleLot Number
          218718

          References

          참고문헌 보기
          Pagano, M.A., et al. 2008. Biochem. J. 415, 353.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-February-2012 RFH
          SynonymsERK8 Inhibitor I, 4,5,6,7-Tetrabromo-2-dimethylamino-1-carboxymethyl-benzimidazole, K66, Erk Inhibitor VI
          DescriptionA cell-permeable tertabromobenzimidazolo TBB (Cat. Nos. 218699 and 218708) analog that acts as a highly selective (IC50 >10 µM against 71 other kinases) ATP-competitive inhibitor against CK2 (IC50 = 500 nM; Ki = 250 nM) and ERK8 (IC50 = 500 nM). K66 is reported to be more selective than either TBB or DMAT and selective CK2 inhibition by K66 is shown to be cytotoxic to non-ERK8-expressing Jurkat cells.
          FormWhite powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number905105-89-7
          Chemical formulaC₁₁H₉Br₄N₃O₂
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (13.3 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          ReferencesPagano, M.A., et al. 2008. Biochem. J. 415, 353.