218826 Caspase-3/7 Inhibitor I - CAS 220509-74-0 - Calbiochem

218826
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      가격 및 재고 조회

      개요

      Replacement Information

      주요 사양표

      Empirical FormulaCAS #
      C₁₄H₁₆N₂O₅S 220509-74-0

      가격 및 재고여부

      카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
      218826-1MGCN
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          Plastic ampoule 1 mg
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          Description
          OverviewA potent, cell-permeable, and specific, reversible inhibitor of caspase-3 (Ki = 60 nM) and caspase-7 (Ki = 170 nM).
          Catalogue Number218826
          Brand Family Calbiochem®
          Synonyms5-[(S)-(+)-2-(Methoxymethyl)pyrrolidino]sulfonylisatin
          References
          ReferencesLee, D., et al. 2001. J. Med. Chem. 44, 2015.
          Lee, D., et al. 2000. J. Biol. Chem. 275, 16007.
          Product Information
          CAS number220509-74-0
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₄H₁₆N₂O₅S
          Chemical formulaC₁₄H₁₆N₂O₅S
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetcaspase-3
          Primary Target K<sub>i</sub> 60 nM, 170 nM, against caspase-3 and caspase-7, respectively
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide Sequence5-[(S)-(+)-2-(Methoxymethyl)pyrrolidino]sulfonylisatin
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Caspase-3/7 Inhibitor I - CAS 220509-74-0 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Caspase-3/7 Inhibitor I - CAS 220509-74-0 - Calbiochem Certificates of Analysis

          TitleLot Number
          218826

          References

          참고문헌 보기
          Lee, D., et al. 2001. J. Med. Chem. 44, 2015.
          Lee, D., et al. 2000. J. Biol. Chem. 275, 16007.

          Brochure

          Title
          Caspases and other Apoptosis Related Tools Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-February-2014 JSW
          Synonyms5-[(S)-(+)-2-(Methoxymethyl)pyrrolidino]sulfonylisatin
          DescriptionA potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (KI(app) = 60 nM) and caspase-7 (KI(app) = 170 nM). Inhibits caspase-9 to a lesser extent (Ki(app) = 3.1 µM). Has only a trivial effect (Ki(app) >25 mM) on the activities of caspase-1, caspase-2, caspase-4, caspase-6, and caspase-8. Reported to inhibit apoptosis in camptothecin treated Jurkat cells (IC50 ~50 µM). Also reported to inhibit apoptosis in chondrocytes (44% inhibition at 10 µM and 98% inhibition at 50 µM). Selectivity for caspases 3 and 7 involves unique hydrophobic residues in the S2 pocket surrounding the catalytic cysteine residue.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number220509-74-0
          Chemical formulaC₁₄H₁₆N₂O₅S
          Peptide Sequence5-[(S)-(+)-2-(Methoxymethyl)pyrrolidino]sulfonylisatin
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (200 mg/ml) or Methanol (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLee, D., et al. 2001. J. Med. Chem. 44, 2015.
          Lee, D., et al. 2000. J. Biol. Chem. 275, 16007.