219007 Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem

219007
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      가격 및 재고 조회

      개요

      Replacement Information

      주요 사양표

      Empirical FormulaCAS #
      C₂₁H₂₈FN₃O₇ 161401-82-7

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      카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
      219007-1MGCN
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          Plastic ampoule 1 mg
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          219007-250UGCN
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              Plastic ampoule 250 μg
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              Description
              OverviewAn irreversible general caspase inhibitor. Useful for studies involving recombinant, isolated, and purified caspase enzymes. Unlike Caspase Inhibitor I (Cat. No. 627610), this inhibitor does not require pretreatment with esterase for in vitro studies. A 10 mM (1 mg/221 µl) solution of Caspase Inhibitor VI (Cat. No. 219011) in DMSO is also available.
              Catalogue Number219007
              Brand Family Calbiochem®
              SynonymsZ-VAD-FMK
              References
              ReferencesMisaghi, S., et al. 2004. Chem. Biol. 11, 1677.
              Product Information
              CAS number161401-82-7
              ATP CompetitiveN
              FormOff-white solid
              Hill FormulaC₂₁H₂₈FN₃O₇
              Chemical formulaC₂₁H₂₈FN₃O₇
              ReversibleN
              Structure formula ImageStructure formula Image
              Quality LevelMQ100
              Applications
              Biological Information
              Primary Targetgeneral caspase inhibitor
              Purity≥98% by HPLC
              Physicochemical Information
              Cell permeableN
              Peptide SequenceZ-Val-Ala-Asp-CH₂F*
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Moisture Protect from moisture
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem MSDS

              타이틀

              물질안전보건자료(MSDS) 

              Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem Certificates of Analysis

              TitleLot Number
              219007

              References

              참고문헌 보기
              Misaghi, S., et al. 2004. Chem. Biol. 11, 1677.

              Brochure

              Title
              Caspases and other Apoptosis Related Tools Brochure

              Citations

              타이틀
            • Liwei Chen, et al. (2005) Chemical ablation of androgen receptor in prostate cancer cells by the histone deacetylase inhibitor LAQ824. Molecular Cancer Therapeutics 4, 1311-1319.
            • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.
            • Yumin Zhang, et al. (2004) Peroxynitrite-Induced Neuronal Apoptosis is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation. Journal of Neuroscience 24, 10616-10627.
            • Dong Zhang, et al. (2001) Granzymes A and B Directly Cleave Lamins and Disrupt the Nuclear Lamina During Granule-Mediated Cytolysis. Proceedings of the National Academy of Science USA 98, 5746-5751.
            • Brian L. Webb, Elsa Jimenez and G. Steven Martin. (2000) v-Src Generates a p53-Independent Apoptotic Signal. Molecular and Cellular Biology 20, 9271-9280.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision17-July-2014 JSW
              SynonymsZ-VAD-FMK
              DescriptionA cell-permeable, irreversible, and general caspase inhibitor. Also reported to inhibit Peptide: N-glycanase (PNGase) in vitro and in vivo. Useful for studies involving recombinant, isolated, and purified caspase enzymes. Unlike Caspase Inhibitor I (Cat. No. 627610), this inhibitor does not require pretreatment with esterase for in vitro studies.
              FormOff-white solid
              CAS number161401-82-7
              Chemical formulaC₂₁H₂₈FN₃O₇
              Peptide SequenceZ-Val-Ala-Asp-CH₂F*
              Structure formulaStructure formula
              Purity≥98% by HPLC
              SolubilityDMSO (9 mg/ml)
              Storage -20°C
              Protect from moisture
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Standard Handling
              ReferencesMisaghi, S., et al. 2004. Chem. Biol. 11, 1677.
              Citation
            • Liwei Chen, et al. (2005) Chemical ablation of androgen receptor in prostate cancer cells by the histone deacetylase inhibitor LAQ824. Molecular Cancer Therapeutics 4, 1311-1319.
            • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.
            • Yumin Zhang, et al. (2004) Peroxynitrite-Induced Neuronal Apoptosis is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation. Journal of Neuroscience 24, 10616-10627.
            • Dong Zhang, et al. (2001) Granzymes A and B Directly Cleave Lamins and Disrupt the Nuclear Lamina During Granule-Mediated Cytolysis. Proceedings of the National Academy of Science USA 98, 5746-5751.
            • Brian L. Webb, Elsa Jimenez and G. Steven Martin. (2000) v-Src Generates a p53-Independent Apoptotic Signal. Molecular and Cellular Biology 20, 9271-9280.