219385 Cathepsin B Inhibitor II - Calbiochem

219385
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      개요

      Replacement Information

      주요 사양표

      Empirical Formula
      C₁₉H₃₆N₄O₄

      가격 및 재고여부

      카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
      219385-1MGCN
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          Plastic ampoule 1 mg
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          Description
          OverviewA more active lysinal analog of Leupeptin (Cat. No. 108975). A more potent inhibitor of cathepsin B (IC50 = 4 nM) compared to leupeptin (IC50 = 310 nM).
          Note: this peptide forms cyclic isomers.
          Catalogue Number219385
          Brand Family Calbiochem®
          SynonymsAc-LVK-CHO
          References
          ReferencesMcConnell, R.M., et al. 1993. J. Med. Chem. 36, 1084.
          Product Information
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₉H₃₆N₄O₄
          Chemical formulaC₁₉H₃₆N₄O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetcathepsin B
          Primary Target IC<sub>50</sub>4 nM against cathepsin B
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceAc-Leu-Val-lysinal
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 1 month at -70°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Cathepsin B Inhibitor II - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Cathepsin B Inhibitor II - Calbiochem Certificates of Analysis

          TitleLot Number
          219385

          References

          참고문헌 보기
          McConnell, R.M., et al. 1993. J. Med. Chem. 36, 1084.

          Brochure

          Title
          Cathepsins and Related Products Technical Bulletin

          Citations

          타이틀
        • Moin U Fareed, et al. (2006) Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 290, R1589-R1597.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-October-2007 RFH
          SynonymsAc-LVK-CHO
          DescriptionLysinal analog of Leupeptin (Cat. No. 108975). A more potent inhibitor of cathepsin B (IC50 = 4 nM) than of leupeptin (IC50 = 310 nM). Note: this peptide forms cyclic isomers.
          FormWhite solid
          Chemical formulaC₁₉H₃₆N₄O₄
          Peptide SequenceAc-Leu-Val-lysinal
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityH₂O (1 mg/ml)
          Storage ≤ -70°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 1 month at -70°C.
          Toxicity Standard Handling
          ReferencesMcConnell, R.M., et al. 1993. J. Med. Chem. 36, 1084.
          Citation
        • Moin U Fareed, et al. (2006) Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 290, R1589-R1597.