219461 Cathepsin K, His•Tag®, Human, Recombinant, E. coli

219461
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      219461-25UGCN
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          Plastic ampoule 25 μg
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          Description
          OverviewCathepsin K is a member of the papain superfamily of cysteine proteinases and plays an important role in osteoclast-mediated bone resorption and collagen degradation. It is primarily expressed by osteoclasts and recent studies also suggest its expression in fibroblasts. Irregularities in cathepsin K activity, either too high or too low, contribute to osteopenic disorders such as osteoporosis and pycnodysostosis. This recombinant enzyme contains a C-terminal His•Tag® sequence.
          Note: 1 mU = 1 milliunit.
          Catalogue Number219461
          Brand Family Calbiochem®
          References
          ReferencesDelaisse, J.M., et al. 2003. Microsc. Res. Tech. 61, 504.
          Dodds, R.A. 2003. Cell Biochem. Funct. 21, 231.
          Everts, V., et al. 2003. Calcif. Tissue Int. 73, 380.
          Hou, W.S., et al. 2003. Biol. Chem. 384, 891.
          Product Information
          CAS number94716-09-3
          Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 0.4 µmol Z-FR-AMC per min at 37°C, pH 5.5.
          EC number3.4.22.38
          FormLiquid
          FormulationIn 50 mM NaOAC, pH 5.5. The activation was stopped by addition of 10 mM MMTS, which can be removed under reducing conditions.
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥95% by SDS-PAGE
          Specific Activity≥900 mU/mg protein
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Cathepsin K, His•Tag®, Human, Recombinant, E. coli MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Cathepsin K, His•Tag®, Human, Recombinant, E. coli Certificates of Analysis

          TitleLot Number
          219461

          References

          참고문헌 보기
          Delaisse, J.M., et al. 2003. Microsc. Res. Tech. 61, 504.
          Dodds, R.A. 2003. Cell Biochem. Funct. 21, 231.
          Everts, V., et al. 2003. Calcif. Tissue Int. 73, 380.
          Hou, W.S., et al. 2003. Biol. Chem. 384, 891.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-March-2013 JSW
          DescriptionCathepsin K is a member of the papain superfamily of cysteine proteinases and plays an important role in osteoclast-mediated bone resorption and collagen degradation. It is primarily expressed by osteoclasts. Recently reported to also be expressed in fibroblasts. Irregularities in activity contribute to osteopenic disorders such as osteoporosis and pycnodysostosis. Contains a C-terminal His•Tag®.
          FormLiquid
          FormulationIn 50 mM NaOAC, pH 5.5. The activation was stopped by addition of 10 mM MMTS, which can be removed under reducing conditions.
          Concentration Label Please refer to vial label for lot-specific concentration
          CAS number94716-09-3
          EC number3.4.22.38
          Purity≥95% by SDS-PAGE
          Specific activity≥900 mU/mg protein
          Unit definitionOne unit is defined as the amount of enzyme that will hydrolyze 0.4 µmol Z-FR-AMC per min at 37°C, pH 5.5.
          Storage ≤ -70°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Standard Handling
          ReferencesDelaisse, J.M., et al. 2003. Microsc. Res. Tech. 61, 504.
          Dodds, R.A. 2003. Cell Biochem. Funct. 21, 231.
          Everts, V., et al. 2003. Calcif. Tissue Int. 73, 380.
          Hou, W.S., et al. 2003. Biol. Chem. 384, 891.