219433 Cathepsin L Inhibitor IV - Calbiochem

219433
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      가격 및 재고 조회

      개요

      Replacement Information

      주요 사양표

      Empirical Formula
      C₂₇H₂₉N₃O₄S

      가격 및 재고여부

      카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
      219433-1MGCN
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          Plastic ampoule 1 mg
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          Description
          OverviewA potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC50 = 1.9 nM). Also inhibits the release of Ca2+ and hydroxyproline from bone in an in vitro bone culture system and prevents bone loss in ovariectomized mice (~50 mg/kg).
          Catalogue Number219433
          Brand Family Calbiochem®
          Synonyms1-Naphthalenesulfonyl-IW-CHO
          References
          ReferencesYasuma, T., et al. 1998. J. Med. Chem. 41, 4301.
          Product Information
          ATP CompetitiveN
          FormWhite to off-white solid
          Hill FormulaC₂₇H₂₉N₃O₄S
          Chemical formulaC₂₇H₂₉N₃O₄S
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetcathepsin L
          Primary Target IC<sub>50</sub>1.9 nM against Cathepsin L
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide Sequence1-Naphthalenesulfonyl-Ile-Trp-CHO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Cathepsin L Inhibitor IV - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Cathepsin L Inhibitor IV - Calbiochem Certificates of Analysis

          TitleLot Number
          219433

          References

          참고문헌 보기
          Yasuma, T., et al. 1998. J. Med. Chem. 41, 4301.

          Citations

          타이틀
        • Moin U Fareed, et al. (2006) Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 290, R1589-R1597.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-January-2019 JSW
          Synonyms1-Naphthalenesulfonyl-IW-CHO
          DescriptionA potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC50 = 1.9 nM). Inhibits the release of Ca2+ and hydroxyproline from bone in a bone culture system and prevents bone loss in ovariectomized mice (~50 mg/kg).
          FormWhite to off-white solid
          Chemical formulaC₂₇H₂₉N₃O₄S
          Peptide Sequence1-Naphthalenesulfonyl-Ile-Trp-CHO
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesYasuma, T., et al. 1998. J. Med. Chem. 41, 4301.
          Citation
        • Moin U Fareed, et al. (2006) Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 290, R1589-R1597.