217694 Cdc25 Inhibitor IV, NSC 95397 - CAS 93718-83-3 - Calbiochem

217694
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      주요 사양표

      Empirical FormulaCAS #
      C₁₄H₁₄O₄S₂ 93718-83-3

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      217694-10MGCN
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable, para-naphthoquinone that has been reported to inhibit protein tyrosine phosphatase activity, including Cdc25 dual specificity phosphatase (Ki = 32 nM, 96 nM, and 40 nM for Cdc25A, -B, and -C, respectively) and blocks G2M transition in murine carcinoma cells. In addition, it is shown to inhibit S100A4 binding to myosin-IIA via covalent modification of cysteine residues, Cys81 and Cys86, in the target binding cleft (IC50 = 1.8 µM). It demonstrates inhibitory activity against S100A4-mediated depolymerization of myosin-IIA filaments.
          Catalogue Number217694
          Brand Family Calbiochem®
          SynonymsPTP Inhibitor XXIX, (2,3-bis-[2-hydroxyethylsulfanyl]-[1,4]naphthoquinone)
          References
          ReferencesDulyaninova, N.G., et al. 2011. Biochemistry 50, 7218.
          Lazo, J.S., et al. 2002. Mol. Pharmacol. 61, 720.
          Product Information
          CAS number93718-83-3
          FormOrange solid
          Hill FormulaC₁₄H₁₄O₄S₂
          Chemical formulaC₁₄H₁₄O₄S₂
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Cdc25 Inhibitor IV, NSC 95397 - CAS 93718-83-3 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Cdc25 Inhibitor IV, NSC 95397 - CAS 93718-83-3 - Calbiochem Certificates of Analysis

          TitleLot Number
          217694

          References

          참고문헌 보기
          Dulyaninova, N.G., et al. 2011. Biochemistry 50, 7218.
          Lazo, J.S., et al. 2002. Mol. Pharmacol. 61, 720.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-June-2012 JSW
          SynonymsPTP Inhibitor XXIX, (2,3-bis-[2-hydroxyethylsulfanyl]-[1,4]naphthoquinone)
          DescriptionA cell-permeable, para-naphthoquinone that has been reported to inhibit protein tyrosine phosphatase activity, including Cdc25 dual specificity phosphatase (Ki = 32 nM, 96 nM, and 40 nM for Cdc25A, -B, and -C, respectively) and blocks G2M transition in murine carcinoma cells. In addition, it is shown to inhibit S100A4 binding to myosin-IIA via covalent modification of cysteine residues, Cys81 and Cys86, in the target binding cleft (IC50 = 1.8 µM). It demonstrates inhibitory activity against S100A4-mediated depolymerization of myosin-IIA filaments.
          FormOrange solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number93718-83-3
          Chemical formulaC₁₄H₁₄O₄S₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (100 mg/ml; clear red solution)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesDulyaninova, N.G., et al. 2011. Biochemistry 50, 7218.
          Lazo, J.S., et al. 2002. Mol. Pharmacol. 61, 720.