219477 Cdk4 Inhibitor II, NSC 625987 - CAS 141992-47-4 - Calbiochem

219477
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      개요

      Replacement Information

      주요 사양표

      Empirical FormulaCAS #
      C₁₅H₁₃NO₂S 141992-47-4

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      219477-5MGCN
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          Glass bottle 5 mg
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          Description
          OverviewA thioacridone compound that acts as a reversible and potent substrate-competitive inhibitor of Cdk4/cyclin D1 (IC50 = 200 nM). Displays ~500-fold greater selectivity for Cdk4/cyclin D1 over Cdc2/cyclin A (Cdk1/cyclin A), Cdk2/cyclin A, and Cdk2/cyclin E (IC50 > 100 µM).
          Catalogue Number219477
          Brand Family Calbiochem®
          Synonyms1,4-Dimethoxyacridine-9(10H)-thione
          References
          ReferencesKubo, A., et al. 1999. Clin. Cancer Res. 5, 4279.
          Product Information
          CAS number141992-47-4
          ATP CompetitiveN
          FormBrown solid
          Hill FormulaC₁₅H₁₃NO₂S
          Chemical formulaC₁₅H₁₃NO₂S
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetCDK4/D1
          Primary Target IC<sub>50</sub>200 nM against CDK4/D1
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Cdk4 Inhibitor II, NSC 625987 - CAS 141992-47-4 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Cdk4 Inhibitor II, NSC 625987 - CAS 141992-47-4 - Calbiochem Certificates of Analysis

          TitleLot Number
          219477

          References

          참고문헌 보기
          Kubo, A., et al. 1999. Clin. Cancer Res. 5, 4279.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision29-December-2009 RFH
          Synonyms1,4-Dimethoxyacridine-9(10H)-thione
          DescriptionA potent, reversible, and substrate-competitive inhibitor of Cdk4/cyclin D1 (IC50 = 200 nM). Displays ~500-fold greater selectivity for Cdk4/cyclin D1 over Cdc2/cyclin A (Cdk1/cyclin A), Cdk2/cyclin A, and Cdk2/cyclin E (IC50 >100 µM).
          FormBrown solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number141992-47-4
          Chemical formulaC₁₅H₁₃NO₂S
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (25 mg/ml) or Ethanol (2.5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesKubo, A., et al. 1999. Clin. Cancer Res. 5, 4279.