219503 Cdk4 Inhibitor V - CAS 943746-57-4 - Calbiochem

219503
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Empirical FormulaCAS #
C₁₉H₁₈IN₃O₄ 943746-57-4

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219503-5MGCN
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      Glass bottle 5 mg
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      Description
      OverviewA cell-permeable and metabolically stable (t1/2 >30 min at 37 °C in rat liver microsomes stability assays) pyridinylmethylamino-isoquinoline dione that acts as a potent, ATP-binding site-targeting Cdk4/D1 inhibitor (IC50 = 30 nM) and an effective antiproliferative agent against HCT116 and MCF-7 cancer cells (IC50 = 0.73 and 0.88 µM, respectively), affecting Cdk2/E and Cdk1/B only at much higher concentrations (IC50 = 1.6 and 25.3 µM, respectively).
      Catalogue Number219503
      Brand Family Calbiochem®
      Synonyms4-(((4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino)-methylene)-6-iodo-4H-isoquinoline-1,3-dione
      References
      ReferencesTsou, H.R., et al. 2009. J. Med. Chem. 52, 2289.
      Product Information
      CAS number943746-57-4
      FormCaramel powder
      Hill FormulaC₁₉H₁₈IN₃O₄
      Chemical formulaC₁₉H₁₈IN₃O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Cdk4 Inhibitor V - CAS 943746-57-4 - Calbiochem MSDS

      타이틀

      물질안전보건자료(MSDS) 

      References

      참고문헌 보기
      Tsou, H.R., et al. 2009. J. Med. Chem. 52, 2289.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-April-2012 JSW
      Synonyms4-(((4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino)-methylene)-6-iodo-4H-isoquinoline-1,3-dione
      DescriptionA cell-permeable and metabolically stable (t1/2 >30 min at 37 °C in the presence of rat liver microsomes, NADPH, and UDPGA) pyridinylmethylamino-isoquinoline dione that acts as a potent, ATP-binding site-targeting inhibitor against Cdk4/D1 kinase activity (IC50 = 30 nM in cell-free Rb c-terminal fragment phosphorylation assays) and an effective antiproliferative agent against HCT116 colorectal and MCF-7 breast cancer cultures (IC50 = 0.73 and 0.88 µM, respectively), while affecting Cdk2/E and Cdk1/B kinase activities only at much higher concentrations (IC50 = 1.6 and 25.3 µM, respectively).
      FormCaramel powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number943746-57-4
      Chemical formulaC₁₉H₁₈IN₃O₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Regulatory Review
      ReferencesTsou, H.R., et al. 2009. J. Med. Chem. 52, 2289.