219493 Ceramide Kinase Inhibitor II, NVP-231 - Calbiochem

219493
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      가격 및 재고 조회

      개요

      Replacement Information

      주요 사양표

      Empirical Formula
      C₂₅H₂₆N₃O₂S

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      카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
      219493-10MGCN
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable benzothiazole compound that potently inhibits Cer (ceramide) phosphorylation by CerK (Cer Kinase) in a reversible and Cer-, but not ATP-, competitive manner (IC50 = 12 nM; Ki = 7.4 nM) with excellent selectivity over hDAGKα (IC50 = 5 µM) and little or no activity against eight other lipid metabolizing enzymes and kinases (IC50 ≥10 µM) in cell-free enzymatic assays. When applied to live cells in cultures, NVP-231 effectively prevents the binding of Cer to CerK, making cellular Cer more available to other Cer metabolizing enzymes and resulting in an increased GlcCer (glucosylceramide) and SM (sphingomyelin) production in addition to the expected decrease of Cer phosphorylation.
          Catalogue Number219493
          Brand Family Calbiochem®
          SynonymsAdamantane-1-carboxylic acid-(2-benzoylamino-benzothiazol-6-yl)-amide, CerK Inhibitor II, NVP-231
          References
          ReferencesGraf, C., et al. 2008. Mol. Pharmacol. 74, 925.
          Product Information
          FormTan solid
          Hill FormulaC₂₅H₂₆N₃O₂S
          Chemical formulaC₂₅H₂₆N₃O₂S
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ceramide Kinase Inhibitor II, NVP-231 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Ceramide Kinase Inhibitor II, NVP-231 - Calbiochem Certificates of Analysis

          TitleLot Number
          219493

          References

          참고문헌 보기
          Graf, C., et al. 2008. Mol. Pharmacol. 74, 925.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-September-2011 RFH
          SynonymsAdamantane-1-carboxylic acid-(2-benzoylamino-benzothiazol-6-yl)-amide, CerK Inhibitor II, NVP-231
          DescriptionA cell-permeable benzothiazole compound that potently inhibits Cer (ceramide) phosphorylation by CerK (Cer Kinase) in a reversible and Cer-, but not ATP-, competitive manner (IC50 = 12 nM; Ki = 7.4 nM) with excellent selectivity over hDAGKα (IC50 = 5 µM) and little or no activity against eight other lipid metabolizing enzymes and kinases (IC50 ≥10 µM) in cell-free enzymatic assays. When applied to live cells in cultures, NVP-231 effectively prevents the binding of Cer to CerK, making cellular Cer more available to other Cer metabolizing enzymes and resulting in an increased GlcCer (glucosylceramide) and SM (sphingomyelin) production in addition to the expected decrease of Cer phosphorylation.
          FormTan solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₅H₂₆N₃O₂S
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (25 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesGraf, C., et al. 2008. Mol. Pharmacol. 74, 925.