215921 Chlorpromazine, Hydrochloride - CAS 69-09-0 - Calbiochem

215921
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      개요

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      주요 사양표

      Empirical FormulaCAS #
      C₁₇H₁₉ClN₂S · HCl 69-09-0

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      215921-500MGCN
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          Alu drum 500 mg
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          Description
          OverviewInhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC50 = 17 µM). Acts as a peripheral vasodilator. Acts as an inhibitor of lysosomal sphingomyelinase and of TNF-α production. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in murine lung. Shown to potently and specifically inhibit KSP/Eg5 (IC50 < 10 µM), and PLA2.
          Catalogue Number215921
          Brand Family Calbiochem®
          Synonyms2-Chloro-10-[3ʹ-(dimethylamino)propyl]phenothiazine, HCl
          References
          ReferencesLee, M.S., et al. 2007. Cancer Res. 67, 11359.
          Maor, I., et al. 1995. Arteriosclero. Thromb. Vasc. Biol. 15, 1378.
          Netea, M.G., et al. 1995. J. Infect. Dis. 171, 393.
          Lindahl, M., and Tagesson, C. 1993. Inflammation 17, 573.
          Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 280.
          Yamamoto, H. 1993. Toxicol. Lett. 66, 73.
          Vadas, P., et al. 1986. Agents Actions 19, 194.
          Marshak, P.R., et al. 1985. Biochemistry 24, 144.
          Product Information
          CAS number69-09-0
          ATP CompetitiveN
          FormOff-white crystalline solid
          Hill FormulaC₁₇H₁₉ClN₂S · HCl
          Chemical formulaC₁₇H₁₉ClN₂S · HCl
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetCalmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase
          Primary Target IC<sub>50</sub>17 µM inhibiting calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase
          Purity≥99% by HPLC
          Physicochemical Information
          Cell permeableN
          ContaminantsHeavy metals: ≤0.002%; iron: ≤0.001%; sulfate: ≤0.05%
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSSO1750000
          Safety Information
          R PhraseR: 25-26-36/37/38

          Toxic if swallowed.
          Very toxic by inhalation.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 22-26-36/37/39-45

          Do not breathe dust.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +15°C to +30°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C and for up to 1 week at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Chlorpromazine, Hydrochloride - CAS 69-09-0 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Chlorpromazine, Hydrochloride - CAS 69-09-0 - Calbiochem Certificates of Analysis

          TitleLot Number
          215921

          References

          참고문헌 보기
          Lee, M.S., et al. 2007. Cancer Res. 67, 11359.
          Maor, I., et al. 1995. Arteriosclero. Thromb. Vasc. Biol. 15, 1378.
          Netea, M.G., et al. 1995. J. Infect. Dis. 171, 393.
          Lindahl, M., and Tagesson, C. 1993. Inflammation 17, 573.
          Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 280.
          Yamamoto, H. 1993. Toxicol. Lett. 66, 73.
          Vadas, P., et al. 1986. Agents Actions 19, 194.
          Marshak, P.R., et al. 1985. Biochemistry 24, 144.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-April-2018 JSW
          Synonyms2-Chloro-10-[3ʹ-(dimethylamino)propyl]phenothiazine, HCl
          DescriptionInhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC50 = 17 µM). Acts as a peripheral vasodilator. An inhibitor of TNFα production. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in murine lung. Shown to potently and specifically inhibit KSP/Eg5 (IC50 < 10 µM), and PLA2.
          FormOff-white crystalline solid
          CAS number69-09-0
          RTECSSO1750000
          Chemical formulaC₁₇H₁₉ClN₂S · HCl
          Structure formulaStructure formula
          Purity≥99% by HPLC
          ContaminantsHeavy metals: ≤0.002%; iron: ≤0.001%; sulfate: ≤0.05%
          SolubilityH₂O (50 mg/ml) or Methanol (10 mg/ml)
          Storage +15°C to +30°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C and for up to 1 week at 4°C.
          Toxicity Toxic
          Merck USA index14, 2185
          ReferencesLee, M.S., et al. 2007. Cancer Res. 67, 11359.
          Maor, I., et al. 1995. Arteriosclero. Thromb. Vasc. Biol. 15, 1378.
          Netea, M.G., et al. 1995. J. Infect. Dis. 171, 393.
          Lindahl, M., and Tagesson, C. 1993. Inflammation 17, 573.
          Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 280.
          Yamamoto, H. 1993. Toxicol. Lett. 66, 73.
          Vadas, P., et al. 1986. Agents Actions 19, 194.
          Marshak, P.R., et al. 1985. Biochemistry 24, 144.

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          카테고리

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Nitric Oxide and Oxidative Stress > Nitric Oxide Synthase (NOS) Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Phosphodiesterase Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Sphingomyelinase Kinase Inhibitors