239805 Cyclopiazonic Acid, Penicillium cyclopium - CAS 18172-33-3 - Calbiochem

239805
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Empirical FormulaCAS #
C₂₀H₂₀N₂O₃ 18172-33-3

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239805-5MGCN
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      Alu drum 5 mg
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      Description
      OverviewA cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca2+-ATPase that releases Ca2+ from the same intracellular pools as Thapsigargin (Cat. No. 586005). Inhibits Ca2+ uptake in cultured arterial smooth muscle cells (IC50 = 560 nM). Also known to inhibit sarcoplasmic reticular Ca2+-ATPase that is distinct from actomyosin ATPase.
      Catalogue Number239805
      Brand Family Calbiochem®
      SynonymsCPA
      References
      ReferencesBadaoui, A., et al. 1995. J. Mol. Cell. Cardiol. 27, 2495.
      Elmoselli, A.B., et al. 1995. Mol. Cell. Biochem. 151, 149.
      Schaefer, A., et al. 1994. J. Biol. Chem. 269, 8786.
      Demaurex, N., et al. 1992. J. Biol. Chem. 267, 2318.
      Low, A.M., et al. 1992. Am. J. Physiol. 262, H31.
      Kurebayashi, N., and Ogawa, Y. 1991. J. Muscle Res. Cell Motil. 12, 355.
      Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856.
      Product Information
      CAS number18172-33-3
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₀H₂₀N₂O₃
      Chemical formulaC₂₀H₂₀N₂O₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCa2+ uptake in cultured arterial musclue cells
      Primary Target IC<sub>50</sub>560 nM inhibiting Ca2+ uptake in cultured arterial smooth muscle cells
      Purity≥97% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSUY8587000
      Safety Information
      R PhraseR: 23/24/25

      Toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36/37/39-45

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Cyclopiazonic Acid, Penicillium cyclopium - CAS 18172-33-3 - Calbiochem MSDS

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      물질안전보건자료(MSDS) 

      Cyclopiazonic Acid, Penicillium cyclopium - CAS 18172-33-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      239805

      References

      참고문헌 보기
      Badaoui, A., et al. 1995. J. Mol. Cell. Cardiol. 27, 2495.
      Elmoselli, A.B., et al. 1995. Mol. Cell. Biochem. 151, 149.
      Schaefer, A., et al. 1994. J. Biol. Chem. 269, 8786.
      Demaurex, N., et al. 1992. J. Biol. Chem. 267, 2318.
      Low, A.M., et al. 1992. Am. J. Physiol. 262, H31.
      Kurebayashi, N., and Ogawa, Y. 1991. J. Muscle Res. Cell Motil. 12, 355.
      Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-April-2008 RFH
      SynonymsCPA
      DescriptionA cell-permeable, reversible inhibitor of endoplasmic reticulum Ca2+-ATPase that releases Ca2+ from the same intracellular pools as thapsigargin. Mobilizes Ca2+ without increasing the levels of Ins(1,4,5)P3. Also known to inhibit sarcoplasmic reticular Ca2+-ATPase that is distinct from actomyosin ATPase. Bay K 8644 (Cat. No. 196878) can reverse the inhibitory effect of cyclopiazonic acid on the refilling of Ca2+ pools that have been depleted by repetitive stimulation with acetylcholine.
      FormOff-white solid
      CAS number18172-33-3
      RTECSUY8587000
      Chemical formulaC₂₀H₂₀N₂O₃
      Structure formulaStructure formula
      Purity≥97% by TLC
      SolubilityChloroform (10 mg/ml) or DMSO (1 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic
      ReferencesBadaoui, A., et al. 1995. J. Mol. Cell. Cardiol. 27, 2495.
      Elmoselli, A.B., et al. 1995. Mol. Cell. Biochem. 151, 149.
      Schaefer, A., et al. 1994. J. Biol. Chem. 269, 8786.
      Demaurex, N., et al. 1992. J. Biol. Chem. 267, 2318.
      Low, A.M., et al. 1992. Am. J. Physiol. 262, H31.
      Kurebayashi, N., and Ogawa, Y. 1991. J. Muscle Res. Cell Motil. 12, 355.
      Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856.