260962 DNA-PK Inhibitor III - CAS 404009-40-1 - Calbiochem

260962
가격 및 재고 조회

개요

Replacement Information

주요 사양표

Empirical FormulaCAS #
C₁₂H₁₅NO₃ 404009-40-1

가격 및 재고여부

카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
260962-1MGCN
재고 정보 검색...
재고 없음재고 없음
예상 출고 가능일 
단종품
제한된 수량 가능
재고여부 확인
    Remaining: will advise
      Remaining: will advise
      추천사항
      고객 서비스로 문의
      Contact Customer Service

      Plastic ampoule 1 mg
      가격 검색...
      가격을 검색할 수 없습니다
      Minimum Quantity needs to be mulitiple of
      가격 문의 추가 정보
      ()이 할인됨
       
      가격 문의
      Description
      OverviewA cell-permeable aryl-morpholino compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 120 nM) and PI 3-Kinase catalytic subunit p110β (IC50 = 135 nM). It inhibits DNA-PK-mediated cellular DNA DSB (double strand break) repair (EC50 = 68 µM) and enhances DSB-induced antitumor activity both in vitro and in vivo, while exhibiting no cytotoxic effects (up to 50 µM) in the absence of DSBs. It inhibits PI 3-K p110α, p110γ, and p110δ only at much higher concentrations (IC50 = 1.4, 0.88, and 1.0 µM, respectively) and exhibits no effect against a panel of several other kinases, including, Cdk2, Src, PKA, PKC, Chk1, CK1, ATM, and FKBP12, even at concentrations as high as 100 µM.
      Catalogue Number260962
      Brand Family Calbiochem®
      SynonymsIC86621, 1-(2-Hydroxy-4-morpholin-4-yl-phenyl)ethanone
      References
      ReferencesKashishian, A., et al. 2004. Mol. Cancer Ther. 2, 1257.
      Willmore, E., et al. 2004. Blood,103, 4659.
      Product Information
      CAS number404009-40-1
      ATP CompetitiveY
      FormOff-white solid
      Hill FormulaC₁₂H₁₅NO₃
      Chemical formulaC₁₂H₁₅NO₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetDNA-PK
      Primary Target IC<sub>50</sub>120 nM against DNA-PK
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      DNA-PK Inhibitor III - CAS 404009-40-1 - Calbiochem MSDS

      타이틀

      물질안전보건자료(MSDS) 

      DNA-PK Inhibitor III - CAS 404009-40-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      260962

      References

      참고문헌 보기
      Kashishian, A., et al. 2004. Mol. Cancer Ther. 2, 1257.
      Willmore, E., et al. 2004. Blood,103, 4659.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-January-2010 RFH
      SynonymsIC86621, 1-(2-Hydroxy-4-morpholin-4-yl-phenyl)ethanone
      DescriptionA cell-permeable, potent, selective, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 0.12 µM) and the PI-3 kinase catalytic subunit p110β (IC50 = 0.135 µM). It inhibits DNA-PK-mediated cellular DNA DSB (double strand break) repair (EC50 = 68 µM) and enhances DSB-induced anti-tumor activity both in vitro and in vivo. Exhibits no cytotoxic effects (up to 50 µM) in the absence of DSBs. It inhibits PI3K p110α, p110γ, and p110δ only at much higher concentrations (IC50 = 1.4 µM, 880 nM, and 1 µM, respectively) and does not inhibit a panel of several other kinases, including, Cdk2, Src, PKA, PKC, Chk1, CK1, ATM, and FKBP12, even at concentrations as high as 100 µM.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number404009-40-1
      Chemical formulaC₁₂H₁₅NO₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesKashishian, A., et al. 2004. Mol. Cancer Ther. 2, 1257.
      Willmore, E., et al. 2004. Blood,103, 4659.