191501 InSolution™ 1-Azakenpaullone - CAS 676596-65-9 - Calbiochem

191501
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      개요

      Replacement Information

      주요 사양표

      Empirical FormulaCAS #
      C₁₅H₁₀BrN₃O 676596-65-9

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      191501-500UGCN
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          Glass bottle 500 μg
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          Description
          OverviewA Kenpaullone (Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC50 = 18 nM). Displays over 100-fold greater selectivity over Cdk1/cyclin B and Cdk5/p25 (IC50 = 2.0 µM and 4.2 µM, respectively). The solid form of this compound (Cat. No. 191500) is also available.
          Catalogue Number191501
          Brand Family Calbiochem®
          References
          ReferencesKunick, C., et al. 2004. Bioorg. Med. Chem. Lett. 14, 413.
          Product Information
          CAS number676596-65-9
          FormLiquid
          FormulationA 10 mM (500 µg/152 µL) solution of 1-Azakenpaullone (Cat. No. 191500) in DMSO.
          Hill FormulaC₁₅H₁₀BrN₃O
          Chemical formulaC₁₅H₁₀BrN₃O
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetGSK-3β
          Primary Target IC<sub>50</sub>18 nM for GSK-3&beta
          Purity≥94% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26-36/37/39

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing, gloves and eye/face protection.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze. Aliquots are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          InSolution™ 1-Azakenpaullone - CAS 676596-65-9 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          InSolution™ 1-Azakenpaullone - CAS 676596-65-9 - Calbiochem Certificates of Analysis

          TitleLot Number
          191501

          References

          참고문헌 보기
          Kunick, C., et al. 2004. Bioorg. Med. Chem. Lett. 14, 413.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision21-September-2012 JSW
          DescriptionA Kenpaullone (Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC50 = 18 nM). Displays over 100-fold greater selectivity over Cdk1/cyclin B and Cdk5/p25 (IC50 = 2.0 µM and 4.2 µM, respectively). The solid form of this compound (Cat. No. 191500) is also available.
          FormLiquid
          FormulationA 10 mM (500 µg/152 µL) solution of 1-Azakenpaullone (Cat. No. 191500) in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          CAS number676596-65-9
          Chemical formulaC₁₅H₁₀BrN₃O
          Structure formulaStructure formula
          Purity≥94% by HPLC
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze. Aliquots are stable for up to 6 months at -20°C.
          Toxicity Irritant
          ReferencesKunick, C., et al. 2004. Bioorg. Med. Chem. Lett. 14, 413.