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118502 InSolution™ ATM Kinase Inhibitor

118502
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개요

Replacement Information

주요 사양표

Empirical Formula
C₂₁H₁₇NO₃S₂

가격 및 재고여부

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118502-2MGCN
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      Glass bottle 2 mg
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      Description
      Catalogue Number118502
      Brand Family Calbiochem®
      References
      ReferencesPereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
      Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
      Hickson, I., et al. 2004. Cancer Res. 64, 9152.
      Product Information
      FormLiquid
      FormulationA 10 mM (2 mg/506 µl) solution of ATM Kinase Inhibitor (Cat. No. 118500) in DMSO.
      Hill FormulaC₂₁H₁₇NO₃S₂
      Chemical formulaC₂₁H₁₇NO₃S₂
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26-36-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ ATM Kinase Inhibitor MSDS

      타이틀

      물질안전보건자료(MSDS) 

      InSolution™ ATM Kinase Inhibitor Certificates of Analysis

      TitleLot Number
      118502

      References

      참고문헌 보기
      Pereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
      Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
      Hickson, I., et al. 2004. Cancer Res. 64, 9152.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-November-2008 JSW
      DescriptionA cell-permeable disubstituted pyranone compound that acts as a potent and ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM; Ki = 2.2 nM). Displays excellent selectivity over other PIKK family kinases (IC50 = 2.5, 9.3, 16.6 µM for DNA-PK, mTOR, PI 3-K, respectively; IC50 > 100 µM for PI 4-K and ATR) and exhibits little activity towards a panel of 60 other kinases even at concentrations as high as 10 µM. Inhibits ATM-dependent cellular protein phosphorylation following ionizing radiation (IR) and sensitizes cells with wild-type ATM, but not mutant ATM, to the cytotoxic effects of IR and DNA-damaging agents.
      FormLiquid
      FormulationA 10 mM (2 mg/506 µl) solution of ATM Kinase Inhibitor (Cat. No. 118500) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₁H₁₇NO₃S₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Irritant
      ReferencesPereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
      Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
      Hickson, I., et al. 2004. Cancer Res. 64, 9152.