Millipore Sigma Vibrant Logo

613570 TIRAP Inhibitor Peptide, Cell-Permeable - Calbiochem

The TIRAP Inhibitor Peptide, Cell-Permeable blocks LPS-, but not CpG-induced NF-κB activation. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ant-Tirap138-151, TIRAP Peptide, Mal Peptide, MyD88-Adapter-Like Peptide, Toll-interleukin 1 Receptor (TIR) domain-containing Adapter Protein Peptide, (RQIKIWFNRRMKWKKLQLRDAAPGGAIVS)

Primary Target: LPS-induced NF-κB activation, PKR phosphorylation, and JNK phosphorylation in RAW.kB cells
View Products on Sigmaaldrich.com
613570
가격 및 재고 조회

개요

Replacement Information

주요 사양표

Empirical Formula
C₁₆₃H₂₆₈N₅₂O₃₈S

가격 및 재고여부

카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
613570-1MGCN
재고 정보 검색...
—
현재 재고 없음 현재 재고 없음
예상 출고 가능일 
단종품
제한된 수량 가능
재고여부 확인
    Remaining: will advise
      Remaining: will advise
      추천사항
      고객 서비스로 문의
      Contact Customer Service

      		 Plastic ampoule 1 mg
      가격 검색...
      가격을 검색할 수 없습니다
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      가격 문의 추가 정보
      ()이 할인됨
       
      —
      가격 문의
      		 —
      Description
      OverviewA cell-permeable synthetic peptide containing mouse TIRAP138-151 fused to the Drosophila Antennapedia sequence. Specifically inhibits LPS-, but not CpG-induced NF-κB activation, PKR phosphorylation, and JNK phosphorylation in RAW.κB cells at ~40 µM. Also reported to block IκBα degradation.
      Catalogue Number613570
      Brand Family Calbiochem®
      SynonymsAnt-Tirap138-151, TIRAP Peptide, Mal Peptide, MyD88-Adapter-Like Peptide, Toll-interleukin 1 Receptor (TIR) domain-containing Adapter Protein Peptide, (RQIKIWFNRRMKWKKLQLRDAAPGGAIVS)
      References
      ReferencesToshchakov, V., et al. 2002. Nat. Immunol. 3, 392.
      Fitzgerald, K.A., et al. 2001. Nature 413, 78.
      Henneke, P. and Golenbock, D.T. 2001. Nat. Immunol. 2, 828.
      Horng, T., et al. 2001. Nat. Immunol. 2, 835.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₆₃H₂₆₈N₅₂O₃₈S
      Chemical formulaC₁₆₃H₂₆₈N₅₂O₃₈S
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetLPS-induced NF-κB activation, PKR phosphorylation, and JNK phosphorylation in RAW.kB cells
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceH-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Leu-Gln-Leu-Arg-Asp-Ala-Ala-Pro-Gly-Gly-Ala-Ile-Val-Ser-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      카탈로그 번호 GTIN
      613570-1MGCN 04055977263558

      Documentation

      TIRAP Inhibitor Peptide, Cell-Permeable - Calbiochem MSDS

      타이틀

      물질안전보건자료(MSDS) 

      TIRAP Inhibitor Peptide, Cell-Permeable - Calbiochem Certificates of Analysis

      TitleLot Number
      613570

      References

      참고문헌 보기
      Toshchakov, V., et al. 2002. Nat. Immunol. 3, 392.
      Fitzgerald, K.A., et al. 2001. Nature 413, 78.
      Henneke, P. and Golenbock, D.T. 2001. Nat. Immunol. 2, 828.
      Horng, T., et al. 2001. Nat. Immunol. 2, 835.

      Brochure

      Title
      Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-September-2008 RFH
      SynonymsAnt-Tirap138-151, TIRAP Peptide, Mal Peptide, MyD88-Adapter-Like Peptide, Toll-interleukin 1 Receptor (TIR) domain-containing Adapter Protein Peptide, (RQIKIWFNRRMKWKKLQLRDAAPGGAIVS)
      DescriptionA synthetic, cell-permeable peptide that corresponds to mouse toll-interleukin 1 receptor (TIR) domain-containing adapter protein 138-151 (TIRAP; also called Mal (MyD88-adapter-like), fused to the Drosophila antennapedia sequence. Shown to specifically inhibit LPS-induced, but not CpG-induced, NF-κB activation, PKR phosphorylation, and JNK phosphorylation in RAW.κB cells at ~40 µM. Also reported to block IκBα degradation.
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₆₃H₂₆₈N₅₂O₃₈S
      Peptide SequenceH-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Leu-Gln-Leu-Arg-Asp-Ala-Ala-Pro-Gly-Gly-Ala-Ile-Val-Ser-OH
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesToshchakov, V., et al. 2002. Nat. Immunol. 3, 392.
      Fitzgerald, K.A., et al. 2001. Nature 413, 78.
      Henneke, P. and Golenbock, D.T. 2001. Nat. Immunol. 2, 828.
      Horng, T., et al. 2001. Nat. Immunol. 2, 835.