5.04713
CPCCOEt
Synonym(s):
CPCCOEt, (E)-Ethyl 1,1a,7,7a-tetrahydro-7-(hydroxyimino)cyclopropa[b]chromene-1a-carboxylate, mGlu1 Antagonist, CPCCOEt
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About This Item
Empirical Formula (Hill Notation):
C13H13NO4
CAS Number:
Molecular Weight:
247.25
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light
assay
≥98% (HPLC)
Quality Segment
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 100 mM
storage temp.
2-8°C
InChI
1S/C13H13NO4/c1-2-17-12(15)13-7-9(13)11(14-16)8-5-3-4-6-10(8)18-13/h3-6,9,16H,2,7H2,1H3/b14-11-
InChI key
FXCTZFMSAHZQTR-KAMYIIQDSA-N
General description
A potent, negative allosteric modulator selective for mGlu1 receptors (IC50 = 6.5 µM). No effect on other mGlu subtype receptors and ionotropic glutamate receptors at concentrations less than 100 µM. Acts by inhibiting an intramolecular interaction between the agonist-bound extracellular domain and the transmembrane domain. Widely used for studies related to peripheral pain and central pain pathways.
Biochem/physiol Actions
Primary Target
mGlu₁ receptors
mGlu₁ receptors
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Luongo L, et al. 2013. Neuropharmacol.66, 317.
Jin, Y., et al. 2012. Pain Res. Treat.2012, 915706.
Tappe-Theodor, A., 2011. Mol Pain.7, 38.
Litschig, S., et al. 1999. Mol. Pharmacol.55, 453.
Annoura, H., et al. 1996. Bioorg. Med. Chem. Lett.6, 763.
Jin, Y., et al. 2012. Pain Res. Treat.2012, 915706.
Tappe-Theodor, A., 2011. Mol Pain.7, 38.
Litschig, S., et al. 1999. Mol. Pharmacol.55, 453.
Annoura, H., et al. 1996. Bioorg. Med. Chem. Lett.6, 763.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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