ABN1009
Anti-TRPA1 Antibody
from rabbit, purified by affinity chromatography
동의어(들):
Transient receptor potential cation channel subfamily A member 1, TRPA1, Ankyrin-like with transmembrane domains protein 1, Transformation-sensitive protein p120
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제품정보 (DICE 배송 시 비용 별도)
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
5
biological source
rabbit
Quality Segment
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
rat, mouse, human
technique(s)
immunohistochemistry: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... TRPA1(8989)
General description
Transient receptor potential A1 (also known as Transient receptor potential ankyrin 1) is an excitatory ion channel on primary sensory nerves of the pain pathway. It is encoded by the TRPA1/ANKTM1 gene in human (Trpa1/Anktm1 in rat & mouse) and plays a critical role in pain associated with tissue injury, inflammation, and nerve lesions. TRPA1 is reported to colocalize with PAR2 and coexpress with TRPV1 (Transient receptor potential vanilloid 1) in rat dorsal root ganglion (DRG) neurons. Agonist-induced TRPA1 current is shown to be enhanced upon PAR2 cleavage/activation by proinflammatory trypsin & tryptase (PMID 17571167). TRPA1 activation, in turn, is reported to result in enhanced TRPV1 phosphorylation and activity in a calcium- and PKA-dependent manner (PMID 24275229).
~130 kDa observed. Uncharacterized band(s) may appear in some lysates.
Immunogen
KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human TRPA1.
Application
Anti-TRPA1 Antibody is an antibody against TRPA1 for use inWestern Blotting and Immunohistochemistry.
Immunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected TRPA1 in rat cerebellum, rat hindbrain, and rat pancreas tissue.
Analysis Note
Evaluated by Western Blotting in rat brain membrane tissue lysate.
Western Blotting Analysis: 0.1 µg/mL of this antibody detected TRPA1 in 10 µg of rat brain membrane tissue lysate.
Western Blotting Analysis: 0.1 µg/mL of this antibody detected TRPA1 in 10 µg of rat brain membrane tissue lysate.
Other Notes
Concentration: Please refer to lot specific datasheet.
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저장 등급
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
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