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MABC95

Anti-S1PR2/EDG5 Antibody, clone 6E8.1

Name: Anti-S1PR2/EDG5 Antibody, clone 6E8.1
Brand: MM

clone 6E8.1, from mouse

Synonym(s):

Sphingosine 1-phosphate receptor 2, S1P receptor 2, S1P2, Endothelial differentiation G-protein coupled receptor 5, Sphingosine 1-phosphate receptor Edg-5, S1P receptor Edg-5

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

6E8.1, monoclonal

Application:

IHC, WB

Citations:

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Properties

biological source

mouse

Quality Segment

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

6E8.1, monoclonal

species reactivity

human

technique(s)

immunohistochemistry: suitable (paraffin), western blot: suitable

isotype

IgMκ

NCBI accession no.

NP_004221

UniProt accession no.

O95136

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... S1PR2(9294)

Description

General description

Sphingosine 1-phosphate receptor 2 (S1PR2), otherwise known as EDG5, is a ubiquitous G-protein coupled receptor for lysosphingolipid sphingosine 1-phosphate (S1P). It is coupled to Gi, G12/13, and Gq pathways to regulate a number of second messengers and effector molecules, including cAMP, PLC, MAPK, RhoA, and Rac. S1PR2 mediates the effects of S1P on cell motility and embryonic development, among other cellular processes.

~35 kDa observed

Immunogen

GST-tagged recombinant protein corresponding to the cytoplasmic domain of human S1PR2/EDG5.

Application

Anti-S1PR2/EDG5 Antibody, clone 6E8.1 detects level of S1PR2/EDG5 & has been published & validated for use in Western Blotting, IHC(P).

Immunohistochemistry Analysis: A representative lot detected S1PR2/EDG5 in human tonsil, liver, colorectal cancer tissues.

Biochem/physiol Actions

This antibody recognizes the cytoplasmic domain of S1PR2/EDG5.

Physical form

Format: Purified

Analysis Note

Evaluated by Western Blot in human liver tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected S1PR2/EDG5 in 10 mg of human liver tissue lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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wgk

WGK 2

flash_point_f

Not applicable

flash_point_c