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Merck

30970

Sodium deoxycholate

BioXtra, ≥98.0% (dry matter, NT)

동의어(들):

3α,12α-Dihydroxy-5β-cholanic acid sodium salt, 7-Deoxycholic acid sodium salt, Desoxycholic acid sodium salt

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C24H39NaO4
CAS 번호:
302-95-4
Molecular Weight:
414.55
UNSPSC Code:
12161900
NACRES:
NA.21
PubChem Substance ID:
57648497
EC Number:
206-132-7
Beilstein/REAXYS Number:
3581950
MDL number:
MFCD00064139

주요 문서

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제품 이름

Sodium deoxycholate, BioXtra, ≥98.0% (dry matter, NT)

InChI

1S/C24H40O4.Na/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3;/h14-21,25-26H,4-13H2,1-3H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-;/m1./s1

InChI key

FHHPUSMSKHSNKW-SMOYURAASA-M

SMILES string

[Na+].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@H]([C@H](C)CCC([O-])=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2

biological source

ox bile

description

anionic

product line

BioXtra

assay

≥98.0% (dry matter, NT)

form

powder

optical activity

[α]20/D +44±2°, c = 2% in H2O

mol wt

micellar avg mol wt 1200-5000

aggregation number

3-12

technique(s)

DNA purification: suitable
RNA purification: suitable
electrophoresis: suitable

impurities

≤1% cholic acid (HPLC)
≤6% water

CMC

2-6 mM (20-25°C)

solubility

water: soluble 1 gm in 10 ml, clear, colorless to very faintly yellow

cation traces

Ca: ≤500 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤10 mg/kg
Mg: ≤10 mg/kg
Mn: ≤5 mg/kg
Ni: ≤5 mg/kg
Pb: ≤10 mg/kg
Zn: ≤5 mg/kg

HLB

16

functional group

carboxylic acid

Quality Level

300

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관련 카테고리

Application

Sodium deoxycholate has been used for preparation of protein extracts for immunoblotting and immunoprecipitation of radiolabeled proteins.

Biochem/physiol Actions

Sodium deoxycholate is a bile salt that stimulates the apical to basolateral accumulation of epirubicin in Caco-2 cells as well as increased serosal absorption of epirubicin in the rat jejunum and ileum. Sodium deoxycholate dissociates histones II from DNA as well as causes lysis of the viral membrane.

Features and Benefits

  • Suitable for Cell Biology and Biochemical Research
  • Can be used in Electrophoresis, DNA and RNA purification
  • Tested to confirm low levels of heavy metal contamination, ensuring suitability for various applications.
  • High purity product for research applications

General description

Sodium Deoxycholate, a bile acid derivative, is a crucial component in biochemical and cell biology research. This water-soluble detergent is widely used in protein-related experiments, including cell lysates and liposome preparation. It aids in membrane protein extraction, lipid compound extraction, and cell nucleus separation. Sodium Deoxycholate is also applied in cholesterol flocculation tests and affinity chromatography for column elution or regeneration. It is commonly used in microbiology for cell lysing, especially because it can be removed from the solution via dialysis.

Sodium Deoxycholate is also utilized in eluting buffers for affinity chromatography and plays a crucial role in DNA and RNA extraction from cells and tissues in molecular biology applications. Additionally, it is used as a catalyst in the preparation of protein extracts for immunoblotting and immunoprecipitation of radiolabeled proteins.

Other Notes

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

저장 등급

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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시험 성적서(COA)

Lot/Batch Number
BCCN6992
BCCN6991
BCCN5723
BCCN2985
BCCN2986

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문서 라이브러리 방문

G Ramadori et al.
The Journal of experimental medicine, 162(3), 930-942 (1985-09-01)
During the acute phase response to tissue injury or inflammation, the concentration of several plasma proteins change. Previous work (29-34) suggested a role for interleukin 1 (IL-1) in the acute phase response. The availability of recombinant-generated mouse IL-1 prompted a
Y L Lo et al.
Biochemical pharmacology, 59(6), 665-672 (2000-02-25)
The effects of sodium deoxycholate (Deo-Na), a bile salt, and sodium caprate (Cap-Na), a fatty acid, on the transport of epirubicin were investigated in both the human colon adenocarcinoma (Caco-2) cell line and the everted gut sacs of the rat
Selective dissociation of histones from chromatin by sodium deoxycholate.
J E Smart et al.
Journal of molecular biology, 58(3), 651-659 (1971-06-28)
A Helenius et al.
Biochimica et biophysica acta, 436(2), 319-334 (1976-06-17)
The effects of increasing concentrations of sodium deoxycholate on Semliki Forest have been studied. Sodium deoxycholate begins to bind to the virus at less than 0.1 mM free equilibrium concentration and causes lysis of the viral membrane at 0.9 +/-
Gang Chen et al.
Autophagy, 8(11), 1577-1589 (2012-08-10)
Ethanol is a neuroteratogen and neurodegeneration is the most devastating consequence of developmental exposure to ethanol. The mechanisms underlying ethanol-induced neurodegeneration are complex. Ethanol exposure produces reactive oxygen species (ROS) which cause oxidative stress in the brain. We hypothesized that
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문서

Simple Digestion Protocol for Proteomics Sample Prep

Rapid trypsin digest kit yields reliable results in less than 2 hours for mass spectrometry analysis.

프로토콜

LPL Activity Assay Protocol

Lipoprotein lipase (LPL) hydrolyzes triglycerides associated with VLDL.

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