A2504
6-Aminocaproic acid
≥99% (titration), powder
동의어(들):
ε-Aminocaproic acid, 6-Aminohexanoic acid, EACA
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
H2N(CH2)5CO2H
CAS 번호:
Molecular Weight:
131.17
UNSPSC Code:
12352202
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-469-3
Beilstein/REAXYS Number:
906872
MDL number:
Assay:
≥99% (titration)
Form:
powder
color
white
InChI key
SLXKOJJOQWFEFD-UHFFFAOYSA-N
InChI
1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)
SMILES string
NCCCCCC(O)=O
biological source
synthetic
assay
≥99% (titration)
form
powder
technique(s)
cell culture | mammalian: suitable
mp
207-209 °C (dec.) (lit.)
solubility
H2O: 50 mg/mL
Quality Level
Gene Information
human ... PLAT(5327), PLG(5340)
rat ... Ppm1a(24666)
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Application
EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.
Biochem/physiol Actions
EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carboxypeptidase, plasmin, and plasminogen activator.
Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis.
Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B.
저장 등급
11 - Combustible Solids
flash_point_f
404.6 - 408.2 °F
flash_point_c
207 - 209 °C
ppe
dust mask type N95 (US), Eyeshields, Gloves
Kazuki Yamamoto et al.
Lab on a chip, 21(10), 1897-1907 (2021-05-20)
Engineered three-dimensional models of neuromuscular tissues are promising for use in mimicking their disorder states in vitro. Although several models have been developed, it is still challenging to mimic the physically separated structures of motor neurons (MNs) and skeletal muscle
E M Van Hoeyveld et al.
The Journal of allergy and clinical immunology, 76(4), 543-550 (1985-10-01)
The effect of epsilon-aminocaproic acid (EACA) on the degradation of an aqueous Lolium perenne extract was studied by intracutaneous tests and by RAST inhibition. Extracts for skin testing stored at 4 degrees C for 12 months and at 37 degrees
Brian Hutton et al.
BMJ (Clinical research ed.), 345, e5798-e5798 (2012-09-13)
To estimate the relative risks of death, myocardial infarction, stroke, and renal failure or dysfunction between antifibrinolytics and no treatment following the suspension of aprotinin from the market in 2008 for safety reasons and its recent reintroduction in Europe and
Moamen Bydoun et al.
Molecular oncology, 12(11), 1895-1916 (2018-07-17)
Pancreatic cancer is arguably the deadliest cancer type. The efficacy of current therapies is often hindered by the inability to predict patient outcome. As such, the development of tools for early detection and risk prediction is key for improving outcome
Sergio Guerrero-Castillo et al.
The EMBO journal, 40(21), e108648-e108648 (2021-09-21)
So-called ρ0 cells lack mitochondrial DNA and are therefore incapable of aerobic ATP synthesis. How cells adapt to survive ablation of oxidative phosphorylation remains poorly understood. Complexome profiling analysis of ρ0 cells covered 1,002 mitochondrial proteins and revealed changes in
문서
Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.
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