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Merck

S6508

Sodium orthovanadate

synthetic (organic), ≥90% (titration), protein tyrosine phosphatase inhibitor, crystalline powder

동의어(들):

Trisodium vanadate

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제품정보 (DICE 배송 시 비용 별도)

Linear Formula:
Na3VO4
CAS 번호:
13721-39-6
Molecular Weight:
183.91
NACRES:
NA.77
PubChem Substance ID:
24899708
UNSPSC Code:
12352200
EC Number:
237-287-9
MDL number:
MFCD00003511

주요 문서

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제품 이름

Sodium orthovanadate, ≥90% (titration)

InChI key

IHIXIJGXTJIKRB-UHFFFAOYSA-N

InChI

1S/3Na.4O.V/q3*+1;;3*-1;

SMILES string

[Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O

biological source

synthetic (organic)

assay

≥90% (titration)

form

crystalline powder

reaction suitability

reagent type: catalyst
core: vanadium

color

white to off-white

mp

850-866 °C (lit.)

solubility

H2O: soluble

Quality Level

200

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관련 카테고리

Application

Sodium orthovandate was used to prepare the stop solution in dephosphorylation assay of insulin receptor kinase.26 It was one of the reagents used in the development of Matrix ChIP that utilizes surface-immobilized antibodies.27

Biochem/physiol Actions

Inhibits ATPase, alkaline phosphatase and tyrosine phosphatase. Decavanadate, which is formed at acidic pH, inhibits inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release from endocrine cells and blocks IP3 binding to its receptor in brain tissue.
Sodium orthovandate suppresses the activation of p53-mediated apoptosis triggered in response to radiation. It reduces the detrimental effects of hematopoietic syndrome, hematopoiesis and delayed genotoxic effects of induced by total body irradiation of mice.24 In combination with menadione, orthovandate prevents the migration of detached human glioma cells in response to anti-cancer drugs.25

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

저장 등급

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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시험 성적서(COA)

Lot/Batch Number
0000268527
0000469370
0000469370
0000268527
0000347365

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문서 라이브러리 방문

C Cerella et al.
Cell death & disease, 6, e1782-e1782 (2015-06-13)
Cardiac glycosides (CGs), prescribed to treat cardiovascular alterations, display potent anti-cancer activities. Despite their well-established target, the sodium/potassium (Na(+)/K(+))-ATPase, downstream mechanisms remain poorly elucidated. UNBS1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin extracted from the plant Calotropis procera, which is
Serena Orlando et al.
Nucleic acids research, 43(14), 6860-6873 (2015-06-15)
Transcriptional repressor complexes containing p130 and E2F4 regulate the expression of genes involved in DNA replication. During the G1 phase of the cell cycle, sequential phosphorylation of p130 by cyclin-dependent kinases (Cdks) disrupts these complexes allowing gene expression. The Cdk
Christopher N J Young et al.
Autophagy, 11(1), 113-130 (2015-02-24)
P2RX7 is an ATP-gated ion channel, which can also exhibit an open state with a considerably wider permeation. However, the functional significance of the movement of molecules through the large pore (LP) and the intracellular signaling events involved are not
Roser Buscà et al.
BMC evolutionary biology, 15, 179-179 (2015-09-04)
The Ras/Raf/MEK/ERK signaling pathway is involved in essential cell processes and it is abnormally activated in ~30 % of cancers and cognitive disorders. Two ERK isoforms have been described, ERK1 and ERK2; ERK2 being regarded by many as essential due
Erika López-Arribillaga et al.
Development (Cambridge, England), 142(1), 41-50 (2014-12-07)
Genetic data indicate that abrogation of Notch-Rbpj or Wnt-β-catenin pathways results in the loss of the intestinal stem cells (ISCs). However, whether the effect of Notch is direct or due to the aberrant differentiation of the transit-amplifying cells into post-mitotic
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Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

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