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121974 ω-Agatoxin IVA, Agelenopsis aperta

121974
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121974-5UG
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      Ampoule plast. 5 μg
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      Description
      OverviewPotent selective high affinity blocker of P-type Ca2+ channels (Kd = 2 nM). Reported to abolish nicotine-evoked responses in cardiac vagal neurons (˜100 nM).
      Catalogue Number121974
      Brand Family Calbiochem®
      Synonymsω-Aga-IVA
      References
      ReferencesWang, J., et al. 2001. J. Neurophysiol. 85, 164.
      Nooney, J.M., and Lodge, D. 1996. Eur. J. Pharmacol. 306, 41.
      Mintz, I.M., et al. 1992. Nature 355, 827.
      Turner, T.J., et al. 1992. Science 258, 310.
      Product Information
      CAS number145017-83-0
      FormWhite powder
      Hill FormulaC₂₂₂H₃₇₁N₆₉O₆₁S₁₁
      Chemical formulaC₂₂₂H₃₇₁N₆₉O₆₁S₁₁
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityPotently inhibits the Cav2.1 channel currents expressed in HEK293 cells.
      Purity≥99% by HPLC
      Physicochemical Information
      Peptide SequenceH-Met-Lys-Lys-Lys-Cys⁵-Ile-Ala-Lys-Asp-Tyr-Gly-Arg-Cys¹³-Lys-Trp-Gly-Gly-Thr-Pro-Cys²⁰-Cys²¹-Arg-Gly-Arg-Gly-Cys²⁶-Ile-Cys²⁸-Ser-Ile-Met-Gly-Thr-Asn-Cys³⁵-Glu-Cys³⁷-Lys-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Gly-Leu-Ala-OH (disulfide bonds: 5 → 21; 13 → 26; 20 → 37; 28 → 35)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and refrigerate (4°C) for short-term storage or freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      ω-Agatoxin IVA, Agelenopsis aperta FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Wang, J., et al. 2001. J. Neurophysiol. 85, 164.
      Nooney, J.M., and Lodge, D. 1996. Eur. J. Pharmacol. 306, 41.
      Mintz, I.M., et al. 1992. Nature 355, 827.
      Turner, T.J., et al. 1992. Science 258, 310.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-May-2011 RB
      Synonymsω-Aga-IVA
      DescriptionA potent and selective blocker of the P-type voltage-dependent Ca2+ channels (Kd = 2 nM).
      FormWhite powder
      CAS number145017-83-0
      Chemical formulaC₂₂₂H₃₇₁N₆₉O₆₁S₁₁
      Peptide SequenceH-Met-Lys-Lys-Lys-Cys⁵-Ile-Ala-Lys-Asp-Tyr-Gly-Arg-Cys¹³-Lys-Trp-Gly-Gly-Thr-Pro-Cys²⁰-Cys²¹-Arg-Gly-Arg-Gly-Cys²⁶-Ile-Cys²⁸-Ser-Ile-Met-Gly-Thr-Asn-Cys³⁵-Glu-Cys³⁷-Lys-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Gly-Leu-Ala-OH (disulfide bonds: 5 → 21; 13 → 26; 20 → 37; 28 → 35)
      Purity≥99% by HPLC
      Biological activityPotently inhibits the Cav2.1 channel currents expressed in HEK293 cells.
      SolubilityH₂O (1 mg/ml) or Saline (1 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and refrigerate (4°C) for short-term storage or freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesWang, J., et al. 2001. J. Neurophysiol. 85, 164.
      Nooney, J.M., and Lodge, D. 1996. Eur. J. Pharmacol. 306, 41.
      Mintz, I.M., et al. 1992. Nature 355, 827.
      Turner, T.J., et al. 1992. Science 258, 310.