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152228 AEG3482

152228
  
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      63735-71-7C₁₀H₈N₄O₂S₂
      Description
      Overview

      This product has been discontinued.





      A cell-permeable imidazothiadiazole compound that activates cellular transcription factor HSF1 by binding to HSP90 and disrupting its association with HSF1. Shown to induce HSF1-dependent expression of HSP70 and HSP25 and effectively block NRAGE- and p75NTR-mediated JNK activation and apoptosis in PC12 cells in a dose-dependent manner (>90% inhibition at 40 µM).
      Catalogue Number152228
      Brand Family Calbiochem®
      Synonyms6-Phenylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide, 281D
      References
      ReferencesSalehi, A.H., et al. 2006. Chem. Biol. 13, 213.
      Product Information
      CAS number63735-71-7
      FormLight yellow solid
      Hill FormulaC₁₀H₈N₄O₂S₂
      Chemical formulaC₁₀H₈N₄O₂S₂
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      AEG3482 Certificats d'analyse

      TitreNuméro de lot
      152228

      Références bibliographiques

      Aperçu de la référence bibliographique
      Salehi, A.H., et al. 2006. Chem. Biol. 13, 213.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-February-2008 JSW
      Synonyms6-Phenylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide, 281D
      DescriptionA cell-permeable imidazothiadiazole compound that activates cellular transcription factor HSF1 by binding to HSP90 and disrupting its association with HSF1. Shown to induce HSF1-dependent expression of HSP70 and HSP25 and effectively block NRAGE- and p75NTR-mediated JNK activation and apoptosis in PC12 cells in a dose-dependent manner (>90% inhibition at 40 µM).
      FormLight yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number63735-71-7
      Chemical formulaC₁₀H₈N₄O₂S₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (~28 mg/ml) or Ethanol (~1.4 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesSalehi, A.H., et al. 2006. Chem. Biol. 13, 213.