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121767 AG 1024 - CAS 65678-07-1 - Calbiochem

121767
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CAS #Empirical Formula
65678-07-1C₁₄H₁₃BrN₂O

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121767-1MG
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      Description
      OverviewA cell-permeable, reversible, substrate competitive, and specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Exhibits lower IC50 values for IGF-1 than for the insulin receptor. Also inhibits insulin-stimulated cellular proliferation.
      Catalogue Number121767
      Brand Family Calbiochem®
      Synonyms3-Bromo-5-t-butyl-4-hydroxy-benzylidenemalonitrile
      References
      ReferencesWen, B., et al. 2001. Br. J. Cancer 85, 2017.
      Parrizas, M., et al. 1997. Endocrinology 138, 1427.
      Ohmichi, M., et al. 1993. Biochemistry 32, 4650.
      Product Information
      CAS number65678-07-1
      ATP CompetitiveN
      FormOff-white to yellow solid
      Hill FormulaC₁₄H₁₃BrN₂O
      Chemical formulaC₁₄H₁₃BrN₂O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetIGF-1
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      AG 1024 - CAS 65678-07-1 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      121767

      Références bibliographiques

      Aperçu de la référence bibliographique
      Wen, B., et al. 2001. Br. J. Cancer 85, 2017.
      Parrizas, M., et al. 1997. Endocrinology 138, 1427.
      Ohmichi, M., et al. 1993. Biochemistry 32, 4650.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      Synonyms3-Bromo-5-t-butyl-4-hydroxy-benzylidenemalonitrile
      DescriptionA cell-permeable, reversible, substrate competitive, and specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor kinases with significantly lower IC50 values for IGF-1 than for insulin receptors. Induces apoptosis by downregulating the expression of phospho-Akt1 and Bcl-2; and increasing the expression of Bax, p53 and p21. Reported to enhance the radiosensitivity of human breast cancer cells.
      FormOff-white to yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number65678-07-1
      Chemical formulaC₁₄H₁₃BrN₂O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Standard Handling
      ReferencesWen, B., et al. 2001. Br. J. Cancer 85, 2017.
      Parrizas, M., et al. 1997. Endocrinology 138, 1427.
      Ohmichi, M., et al. 1993. Biochemistry 32, 4650.