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118501 ATM/ATR Kinase Inhibitor - CAS 905973-89-9 - Calbiochem

118501
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CAS #Empirical Formula
905973-89-9C₂₃H₁₈Cl₃FN₄O₃S

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118501-5MG
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      Description
      OverviewA cell-permeable thiourea compound that selectively inhibits the kinase activity of ATM and ATR (IC50 = ~200 nM) without significant effect against other PIKK family members (PI 3-K, mTOR, and DNA-PK) or kinases that are known to phosphorylate p53 (ERK, CK1, Cdk2, JNK, PKC, CAK, Chk1, PKR, and p38). Shown to reverse senescence in human primary BJ and HMEC cells. Unlike LY 294002 (Cat. No. 440202 and 440204), this inhibitor does not interfere with cellular PI 3-K/PDK1/Akt signaling pathway.
      Catalogue Number118501
      Brand Family Calbiochem®
      SynonymsCGK 733
      References
      ReferencesGoldstein, M., et al. 2008. Toxicol. Appl. Pharmacol. in press.
      Crescenzi, E., et al. 2008. Clin. Cancer Res. 14, 1877.
      Cruet-Hennequart, S., et al. 2008. DNA Repair 7, 582.
      Won, J., et al. 2006. Nat. Chem. Biol. 2, 369. (RETRACTED)
      Product Information
      CAS number905973-89-9
      ATP CompetitiveN
      FormPale yellow solid
      Hill FormulaC₂₃H₁₈Cl₃FN₄O₃S
      Chemical formulaC₂₃H₁₈Cl₃FN₄O₃S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetATM/ATR
      Primary Target IC<sub>50</sub>~200 nM against ATM and ATR
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      ATM/ATR Kinase Inhibitor - CAS 905973-89-9 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      118501

      Références bibliographiques

      Aperçu de la référence bibliographique
      Goldstein, M., et al. 2008. Toxicol. Appl. Pharmacol. in press.
      Crescenzi, E., et al. 2008. Clin. Cancer Res. 14, 1877.
      Cruet-Hennequart, S., et al. 2008. DNA Repair 7, 582.
      Won, J., et al. 2006. Nat. Chem. Biol. 2, 369. (RETRACTED)
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-June-2008 JSW
      SynonymsCGK 733
      DescriptionA cell-permeable thiourea compound that selectively inhibits the kinase activity of ATM and ATR (IC50 ~ 200 nM) without significant effect against other PIKK family members (PI3K, mTOR, and DNA-PK) or kinases that are known to phosphorylate p53 (ERK, CK1, Cdk2, JNK, PKC, CAK, Chk1, PKR, and p38). Shown to reverse senescence in human primary BJ and HMEC cells. Unlike LY 294002 (Cat. No. 440202 and 440204), this inhibitor does not interfere with cellular PI3K-PDK1-Akt signaling pathway.
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number905973-89-9
      Chemical formulaC₂₃H₁₈Cl₃FN₄O₃S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesGoldstein, M., et al. 2008. Toxicol. Appl. Pharmacol. in press.
      Crescenzi, E., et al. 2008. Clin. Cancer Res. 14, 1877.
      Cruet-Hennequart, S., et al. 2008. DNA Repair 7, 582.
      Won, J., et al. 2006. Nat. Chem. Biol. 2, 369. (RETRACTED)