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116860 Adenosine Deaminase Inhibitor, DCF - CAS 53910-25-1 - Calbiochem

116860
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CAS #Empirical Formula
53910-25-1C₁₁H₁₆N₄O₄

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116860-10MG
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      Description
      OverviewA cell-permeable purine nucleoside compound that acts as a highly potent, tight binding transition state analog inhibitor of adenosine deaminase (ADA; Ki= 2.5 pM against partially purified human erythrocytes, and 0.48 to 9.1 nM against rat liver, rat intestine, rat hepatoma and human B cells). Reported to be an immunomodulator and exert selective toxicity towards lymphocytes.
      Catalogue Number116860
      Brand Family Calbiochem®
      Synonyms2ʹ-Deoxycoformycin, (8R)-3-(2-deoxy-β-D-erythro- pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, Pentostatin, S. antibioticus
      References
      ReferencesRobak, T. 2007. Cancer Treat. Rev. 33, 710.
      Klohs, W.D. and Kraker, A.J., 1992. Pharmacol. Rev. 44, 459.
      Agarwal, R.P., et al. 1977. Biochem. Pharmacol. 26, 359.
      Product Information
      CAS number53910-25-1
      FormWhite solid
      Hill FormulaC₁₁H₁₆N₄O₄
      Chemical formulaC₁₁H₁₆N₄O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 62-63

      Possible risk of impaired fertility.
      Possible risk of harm to the unborn child.
      S PhraseS: 36/37/39-45

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Harmful & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Adenosine Deaminase Inhibitor, DCF - CAS 53910-25-1 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Adenosine Deaminase Inhibitor, DCF - CAS 53910-25-1 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      116860

      Références bibliographiques

      Aperçu de la référence bibliographique
      Robak, T. 2007. Cancer Treat. Rev. 33, 710.
      Klohs, W.D. and Kraker, A.J., 1992. Pharmacol. Rev. 44, 459.
      Agarwal, R.P., et al. 1977. Biochem. Pharmacol. 26, 359.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-May-2012 JSW
      Synonyms2ʹ-Deoxycoformycin, (8R)-3-(2-deoxy-β-D-erythro- pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, Pentostatin, S. antibioticus
      DescriptionA cell-permeable purine nucleoside compound that acts as a highly potent, tight binding transition state analog inhibitor of adenosine deaminase (ADA; Ki= 2.5 pM against partially purified human erythrocytes, and 0.48 to 9.1 nM against rat liver, rat intestine, rat hepatoma and human B cells). Reported to be an immunomodulator and exert selective toxicity towards lymphocytes.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number53910-25-1
      Chemical formulaC₁₁H₁₆N₄O₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml; clear, colorless solution) or H₂O (50 mg/ml; clear, colorless solution)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      ReferencesRobak, T. 2007. Cancer Treat. Rev. 33, 710.
      Klohs, W.D. and Kraker, A.J., 1992. Pharmacol. Rev. 44, 459.
      Agarwal, R.P., et al. 1977. Biochem. Pharmacol. 26, 359.