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116890 Adenosine Kinase Inhibitor - CAS 214697-26-4 - Calbiochem

116890
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CAS #Empirical Formula
214697-26-4C₂₂H₁₉BrN₆O

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116890-5MG
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      Description
      OverviewA cell-permeable, non-nucleoside pyridopyrimidine compound that acts as a potent, adenosine-competitive, and reversible adenosine kinase (AK) inhibitor (IC50 = 50.7 nM using intact IMR-32 cells and 1.7 nM in cell-free assays using rat brain cytosolic AK). The inhibitory effect is not species-specific and its pharmacological selectivity is confirmed using a panel of more than 80 other enzymes, ion channels, and receptors, including various adesine receptors. It readily crosses the blood-brain barrier and is shown to be efficacious in in vivo animal models via various administration methods (i.p., p.o., s.c.).

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without salt molecules.
      Catalogue Number116890
      Brand Family Calbiochem®
      Synonyms4-Amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, 2HCl, ABT-702
      References
      ReferencesDe Vry, J., et al. 2004. Eur. J. Pharmacol. 491, 137.
      Suzuki, R., et al. 2001. Br. J. Pharmacol. 132, 1615.
      Boyle, D.L., et al. 2001. J. Pharmacol. Exp. Ther. 296, 495.
      Kowaluk, E.A., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1165.
      Jarvis, M.F., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1156.
      Product Information
      CAS number214697-26-4
      ATP CompetitiveN
      FormYellow to orange solid
      Hill FormulaC₂₂H₁₉BrN₆O
      Chemical formulaC₂₂H₁₉BrN₆O
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAdenosine Kinase
      Primary Target IC<sub>50</sub>50.7 nM inhibiting adenosine kinase (AK) using intact IMR-32 cells and 1.7 nM in cell-free assays using rat brain cytosolic AK
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Adenosine Kinase Inhibitor - CAS 214697-26-4 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      116890

      Références bibliographiques

      Aperçu de la référence bibliographique
      De Vry, J., et al. 2004. Eur. J. Pharmacol. 491, 137.
      Suzuki, R., et al. 2001. Br. J. Pharmacol. 132, 1615.
      Boyle, D.L., et al. 2001. J. Pharmacol. Exp. Ther. 296, 495.
      Kowaluk, E.A., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1165.
      Jarvis, M.F., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1156.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-December-2018 JSW
      Synonyms4-Amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, 2HCl, ABT-702
      DescriptionA cell-permeable, non-nucleoside pyridopyrimidine compound that acts as a potent, adenosine-competitive, and reversible adenosine kinase (AK) inhibitor (IC50 = 50.7 nM using intact IMR-32 cells and 1.7 nM in cell-free assays using rat brain cytosolic AK). The inhibitory effect is not species-specific and its pharmacological selectivity is confirmed using a panel of more than 80 other enzymes, ion channels, and receptors, including various adesine receptors. It readily crosses the blood-brain barrier and is shown to be efficacious in in vivo animal models via various administration methods (i.p., p.o., s.c.).
      FormYellow to orange solid
      CAS number214697-26-4
      Chemical formulaC₂₂H₁₉BrN₆O
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (20 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesDe Vry, J., et al. 2004. Eur. J. Pharmacol. 491, 137.
      Suzuki, R., et al. 2001. Br. J. Pharmacol. 132, 1615.
      Boyle, D.L., et al. 2001. J. Pharmacol. Exp. Ther. 296, 495.
      Kowaluk, E.A., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1165.
      Jarvis, M.F., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1156.