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124008 Akt Inhibitor II - Calbiochem

124008
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Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₂₉H₅₉O₁₀P

Prix & Disponibilité

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124008-1MG
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      Description
      OverviewA cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt and select downstream substrates without decreasing phosphorylation of PDK-1 or other kinases downstream of Ras, such as MAPK. Also acts as a potent inducer of apoptosis and selectively kills a variety of cancer cell lines that contain high levels of active Akt. When used at a concentration of 10 µM, it is reported to activate p38α/SAPK2α MAP kinase. At 10 µM it will also inhibit ~50% of PKA activity.
      Catalogue Number124008
      Brand Family Calbiochem®
      SynonymsSH-5
      References
      ReferencesGills, J.J., et al. 2007. J. Biol. Chem. in press.
      Kozikowski, A.P., et al. 2003. J. Am. Chem. Soc.125, 1144.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₉H₅₉O₁₀P
      Chemical formulaC₂₉H₅₉O₁₀P
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationAkt Inhibitor II, CAS 701976-54-7, is a cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt & downstream substrates.
      Biological Information
      Primary TargetAkt
      Purity≥98% by NMR
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Akt Inhibitor II - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Akt Inhibitor II - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      124008

      Références bibliographiques

      Aperçu de la référence bibliographique
      Gills, J.J., et al. 2007. J. Biol. Chem. in press.
      Kozikowski, A.P., et al. 2003. J. Am. Chem. Soc.125, 1144.

      Brochure

      Titre
      Akt
      Biologics 31.1
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-November-2009 RFH
      SynonymsSH-5
      DescriptionA cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt and selected downstream substrates without affecting the phosphorylation of PDK-1 and other downstream kinases. Decreases phosphorylation of Akt without affecting the total Akt level. Reported to be a potent inducer of apoptosis and to selectively kill a variety of cancer cell lines expressing high levels of active Akt. When used at a concentration of 10 µM, it is reported to activate p38α/SAPK2α MAP kinase. At 10 µM it will also inhibit ~50% of PKA activity.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₉H₅₉O₁₀P
      Structure formulaStructure formula
      Purity≥98% by NMR
      SolubilityDMSO (10 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesGills, J.J., et al. 2007. J. Biol. Chem. in press.
      Kozikowski, A.P., et al. 2003. J. Am. Chem. Soc.125, 1144.