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236015 COX-2 Inhibitor V, FK3311 - CAS 116686-15-8 - Calbiochem

236015
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Empirical FormulaCAS #
C₁₅H₁₃F₂NO₄S 116686-15-8

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236015-5MG
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      Description
      OverviewA cell-permeable and orally available sulfonanilide that acts as a COX-2-selective non-steroidal anti-inflammatory drug (NSAID). Shown to exhibit 500-fold greater potency in inhibiting the LPS-induced (IC50 = 316 nM in human mononuclear cells) than the non-induced/constitutive (IC50 = 160 µM in human platelets) TxB2 production in vitro and effectively alleviate warm ischemia-reperfusion injury in the canine liver and rat lung in vivo.
      Catalogue Number236015
      Brand Family Calbiochem®
      Synonyms4ʹ-Acetyl-2ʹ-(2,4-Difluorophenoxy)methanesulfonanilide
      References
      ReferencesOtani, Y., et al. 2007. J. Invest. Surg. 20, 175.
      Sunose, Y., et al. 2001. Transplant Proc. 33, 862.
      Grossman, C.J., et al. 1995. Inflamm. Res. 44, 253.
      Nakamura, K., et al. 1993. Chem. Pharm. Bull. 41, 2050.
      Tsuji, K., et al. 1992. Chem. Pharm. Bull. 40, 2399.
      Product Information
      CAS number116686-15-8
      FormWhite solid
      Hill FormulaC₁₅H₁₃F₂NO₄S
      Chemical formulaC₁₅H₁₃F₂NO₄S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25-36/39

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      COX-2 Inhibitor V, FK3311 - CAS 116686-15-8 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      236015

      Références bibliographiques

      Aperçu de la référence bibliographique
      Otani, Y., et al. 2007. J. Invest. Surg. 20, 175.
      Sunose, Y., et al. 2001. Transplant Proc. 33, 862.
      Grossman, C.J., et al. 1995. Inflamm. Res. 44, 253.
      Nakamura, K., et al. 1993. Chem. Pharm. Bull. 41, 2050.
      Tsuji, K., et al. 1992. Chem. Pharm. Bull. 40, 2399.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-March-2009 RFH
      Synonyms4ʹ-Acetyl-2ʹ-(2,4-Difluorophenoxy)methanesulfonanilide
      DescriptionA cell-permeable and orally available sulfonanilide that acts as a COX-2-selective non-steroidal anti-inflammatory drug (NSAID). Shown to exhibit 500-fold greater potency in inhibiting the LPS-induced (IC50 = 316 nM in human mononuclear cells) than the non-induced/constitutive (IC50 = 160 µM in human platelets) TxB2 production in vitro and effectively alleviate warm ischemia-reperfusion injury in the canine liver and rat lung in vivo.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number116686-15-8
      Chemical formulaC₁₅H₁₃F₂NO₄S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (30 mg/ml) or Ethanol (15 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesOtani, Y., et al. 2007. J. Invest. Surg. 20, 175.
      Sunose, Y., et al. 2001. Transplant Proc. 33, 862.
      Grossman, C.J., et al. 1995. Inflamm. Res. 44, 253.
      Nakamura, K., et al. 1993. Chem. Pharm. Bull. 41, 2050.
      Tsuji, K., et al. 1992. Chem. Pharm. Bull. 40, 2399.