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215901 Carbonic Anhydrase IX/XII Inhibitor II, U-104 - Calbiochem

215901
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Tableau de caractéristiques principal

Empirical Formula
C₁₃H₁₂FN₃O₃S

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215901-5MG
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      Description
      OverviewA cell permeable ureido-sulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (Ki = 45 nM and 4.5 nM, respectively) against two other physiologically relevant hCA isoforms (Ki = 5080 nM and 9640 nM for hCA I and hCA II, respectively). It elicits anti-tumor growth effects dose-dependently from 19 to 38 mg/kg in a mouse tumor growth model implanted with MDA-MB-231 LM2-4Luc+ cells, and demonstrates metastasis inhibition in a mouse metastasis model injected with 4T1 cells.
      Catalogue Number215901
      Brand Family Calbiochem®
      SynonymsCAIX Inhibitor II
      References
      ReferencesLock, F.E., et al. 2012. Oncogene in press.
      Pacchiano, F., et al. 2011. J Med Chem. 54, 1896.
      Product Information
      FormWhite solid
      Hill FormulaC₁₃H₁₂FN₃O₃S
      Chemical formulaC₁₃H₁₂FN₃O₃S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Références bibliographiques

      Aperçu de la référence bibliographique
      Lock, F.E., et al. 2012. Oncogene in press.
      Pacchiano, F., et al. 2011. J Med Chem. 54, 1896.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-December-2012 JSW
      SynonymsCAIX Inhibitor II
      DescriptionA cell permeable ureido-sulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (Ki = 45 nM and 4.5 nM, respectively) against two other physiologically relevant hCA isoforms (Ki = 5080 nM and 9640 nM for hCA I and hCA II, respectively). It elicits anti-tumor growth effects dose-dependently from 19 to 38 mg/kg in a mouse tumor growth model implanted with MDA-MB-231 LM2-4Luc+ cells, and demonstrates metastasis inhibition in a mouse metastasis model injected with 4T1 cells.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₃H₁₂FN₃O₃S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Regulatory Review
      ReferencesLock, F.E., et al. 2012. Oncogene in press.
      Pacchiano, F., et al. 2011. J Med Chem. 54, 1896.