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138001 D-Amino Acid Oxidase Inhibitor II, CBIO - CAS 61977-29-5 - Calbiochem

138001
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CAS #Empirical Formula
61977-29-5C₇H₄ClNO₂

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138001-50MG
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      Description
      OverviewA cell-permeable benzisoxazolone compound that potently inhibits D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) activity (IC50 = 90 and 150/188 nM against rat spinal cord and porcine kidney DAO, respectively) in a reversible and D-serine-competitive (Ki = 100 nM) manner. Upon co-administration, CBIO (30 mg/kg, p.o.) markedly prolongs the half-life of orally administered D-serine (30 mg/kg) in plasma, resulting in enhanced rat brain D-serine level (60% vs. 25% above basal, respectively, with vs. without CBIO). Direct intrathecal/spinal CBIO injection either before (ED50 =60 ng) or after (ED50 = 170 ng) subcutaneous formalin injection (50 µl 5% solution) greatly alleviates formalin-induced late phase tonic pain (Emax =67%), but not early phase acute nociception in rats in vivo.
      Catalogue Number138001
      Brand Family Calbiochem®
      Synonyms6-Chloro-1,2-benzisoxazol-3(2H)-one, 6-Chlorobenzo[d]isoxazol-3-ol, D-AAO Inhibitor II, CBIO
      References
      ReferencesGong, N., et al. 2011. J. Pharmacol. Exp. Ther. 336, 282.
      Ferraris, D., et al. 2008. J. Med. Chem. 51, 3357.
      Product Information
      CAS number61977-29-5
      FormOff-white powder
      Hill FormulaC₇H₄ClNO₂
      Chemical formulaC₇H₄ClNO₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      D-Amino Acid Oxidase Inhibitor II, CBIO - CAS 61977-29-5 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      D-Amino Acid Oxidase Inhibitor II, CBIO - CAS 61977-29-5 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      138001

      Références bibliographiques

      Aperçu de la référence bibliographique
      Gong, N., et al. 2011. J. Pharmacol. Exp. Ther. 336, 282.
      Ferraris, D., et al. 2008. J. Med. Chem. 51, 3357.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-October-2011 RFH
      Synonyms6-Chloro-1,2-benzisoxazol-3(2H)-one, 6-Chlorobenzo[d]isoxazol-3-ol, D-AAO Inhibitor II, CBIO
      DescriptionA cell-permeable benzisoxazolone compound that potently inhibits D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) activity (IC50 = 90 and 150/188 nM against rat spinal cord and porcine kidney DAO, respectively) in a reversible and D-serine-competitive (Ki = 100 nM) manner. Upon co-administration, CBIO (30 mg/kg, p.o.) markedly prolongs the half-life of orally administered D-serine (30 mg/kg) in plasma, resulting in enhanced rat brain D-serine level (60% vs. 25% above basal, respectively, with vs. without CBIO). Direct intrathecal/spinal CBIO injection either before (ED50 =60 ng) or after (ED50 = 170 ng) subcutaneous formalin injection (50 µl 5% solution) greatly alleviates formalin-induced late phase tonic pain (Emax =67%), but not early phase acute nociception in rats in vivo.
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number61977-29-5
      Chemical formulaC₇H₄ClNO₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (50 mg/ml). It is recommended to prepare a stock solution for 6 month use each time and store the unreconstituted material in solid form, protected from moisture and preferably under inert gas, for best long-term stability during storage.
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesGong, N., et al. 2011. J. Pharmacol. Exp. Ther. 336, 282.
      Ferraris, D., et al. 2008. J. Med. Chem. 51, 3357.