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287895 Drosophila Antennapedia Homeo-Domain (43-58) - Calbiochem

287895
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Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₁₀₄H₁₆₈N₃₄O₂₀S

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287895-1MG
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      Ampoule plast. 1 mg
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      Description
      OverviewThe membrane translocation signal sequence from Drosophila Antennapedia homeo-domain (43-58) that is reported to act as an inhibitor of protein kinase G Iα (Ki = 970 nM). Does not exhibit significant inhibition against protein kinase A (PKA) (Ki = 107 µM). May be useful for intracellular delivery of highly charged peptides by covalent attachment.
      Catalogue Number287895
      Brand Family Calbiochem®
      SynonymsDT-5, RQIKIWFQNRRMKWKK, PKG Inhibitor V
      References
      ReferencesDostman, W.R.G., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 14772.
      Derossi, D., et al. 1998. Trends Cell Biol. 8, 84.
      Product Information
      ATP CompetitiveN
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₀₄H₁₆₈N₃₄O₂₀S
      Chemical formulaC₁₀₄H₁₆₈N₃₄O₂₀S
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKG1α
      Primary Target K<sub>i</sub>970 nM against protein kinase G Iα
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Drosophila Antennapedia Homeo-Domain (43-58) - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      287895

      Références bibliographiques

      Aperçu de la référence bibliographique
      Dostman, W.R.G., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 14772.
      Derossi, D., et al. 1998. Trends Cell Biol. 8, 84.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-June-2008 RFH
      SynonymsDT-5, RQIKIWFQNRRMKWKK, PKG Inhibitor V
      DescriptionThe membrane translocation signal sequence from Drosophila Antennapedia homeo-domain (43-58) that has been shown to inhibit protein kinase G Iα (PKG Iα) (Ki = 970 nM). Does not exhibit significant inhibition against protein kinase A (PKA) (Ki = 107 µM). May also be useful for intracellular delivery of highly charged peptides by covalent attachment.
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₀₄H₁₆₈N₃₄O₂₀S
      Peptide SequenceH-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesDostman, W.R.G., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 14772.
      Derossi, D., et al. 1998. Trends Cell Biol. 8, 84.