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124038 InSolution™ Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem

124038
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Tableau de caractéristiques principal

CAS #Empirical Formula
35943-35-2C₁₃H₁₆N₆O₄

Prix & Disponibilité

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124038-2MG
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      Description
      OverviewA cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥60% in cell proliferation at 20 µM) and in vivo (≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.).
      Catalogue Number124038
      Brand Family Calbiochem®
      References
      ReferencesKarst, A., et al. 2006. Cancer Res. 66, 9225.
      Yang, L., et al. 2004. Cancer Res. 64, 4394.
      Product Information
      CAS number35943-35-2
      FormLiquid
      FormulationA 2 mg/312 µl solution of Akt Inhibitor V, Triciribine (Cat. No. 124012) in DMSO.
      Hill FormulaC₁₃H₁₆N₆O₄
      Chemical formulaC₁₃H₁₆N₆O₄
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSRY8455000
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing intitial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      InSolution™ Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      124038

      Références bibliographiques

      Aperçu de la référence bibliographique
      Karst, A., et al. 2006. Cancer Res. 66, 9225.
      Yang, L., et al. 2004. Cancer Res. 64, 4394.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-January-2012 RFH
      DescriptionA cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥60% in cell proliferation at 20 µM) and in vivo (≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.).
      FormLiquid
      FormulationA 2 mg/312 µl solution of Akt Inhibitor V, Triciribine (Cat. No. 124012) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number35943-35-2
      RTECSRY8455000
      Chemical formulaC₁₃H₁₆N₆O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage ≤ -70°C
      Hygroscopic
      Protect from light
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing intitial thaw, aliquot and freeze (-70°C).
      Toxicity Irritant
      ReferencesKarst, A., et al. 2006. Cancer Res. 66, 9225.
      Yang, L., et al. 2004. Cancer Res. 64, 4394.