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124039 InSolution™ Akt Inhibitor X - CAS 925681-41-0 - Calbiochem

124039
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CAS #Empirical Formula
925681-41-0C₂₀H₂₅ClN₂O • HCl

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124039-2MG
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      Description
      OverviewA cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition < 5 µM) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 µM), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2 (Cat. No. 124018), the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein. The solid form of this compound (Cat. No. 124020) is also available.
      Catalogue Number124039
      Brand Family Calbiochem®
      Synonyms10-DEBC HC, 10-(4ʹ-(N,N-Diethylamino)butyl)-2-chlorophenoxazine, HCl, 4-(2-Chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine, HCl
      References
      ReferencesTsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 16982.
      Thimmaiah, K.N., et al. 2005. J. Biol. Chem. 280, 31924.
      Product Information
      CAS number925681-41-0
      FormLiquid
      FormulationA 20 mM (2 mg/262 µL) solution of Akt Inhibitor X (Cat. No. 124020) in H₂O.
      Hill FormulaC₂₀H₂₅ClN₂O • HCl
      Chemical formulaC₂₀H₂₅ClN₂O • HCl
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAkt
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Protect from Light Protect from light
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ Akt Inhibitor X - CAS 925681-41-0 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Tsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 16982.
      Thimmaiah, K.N., et al. 2005. J. Biol. Chem. 280, 31924.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-December-2012 JSW
      Synonyms10-DEBC HC, 10-(4ʹ-(N,N-Diethylamino)butyl)-2-chlorophenoxazine, HCl, 4-(2-Chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine, HCl
      DescriptionA cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition < 5 µM) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 µM), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2 (Cat. No. 124018), the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein. The solid form of this compound (Cat. No. 124020) is also available.
      FormLiquid
      FormulationA 20 mM (2 mg/262 µL) solution of Akt Inhibitor X (Cat. No. 124020) in H₂O.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number925681-41-0
      Chemical formulaC₂₀H₂₅ClN₂O • HCl
      Structure formulaStructure formula
      Purity≥97% by HPLC
      Storage ≤ -70°C
      Protect from light
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
      Toxicity Standard Handling
      ReferencesTsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 16982.
      Thimmaiah, K.N., et al. 2005. J. Biol. Chem. 280, 31924.