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235427 InSolution™ Caspase-3 Inhibitor I, Cell-Permeable - Calbiochem

235427
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Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₉₄H₁₅₈N₂₀O₂₇

Prix & Disponibilité

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235427-1MG
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      Description
      Catalogue Number235427
      Brand Family Calbiochem®
      SynonymsCell-permeable, DEVD-CHO; CPP32/Apopain Inhibitor, Cell-permeable
      References
      ReferencesLin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305.
      Nicholson, D.W. 1996. Nature Biotechnol. 14, 297.
      Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
      Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
      Nicholson, D.W., et al. 1995. Nature 376, 37.
      Tewari, M., et al. 1995. Cell 81, 801.
      Lazebnik, Y.A., et al. 1994. Nature 371, 346.
      Product Information
      ATP CompetitiveN
      FormLiquid
      FormulationA 5 mM (1 mg/100 µl) solution of Caspase-3 Inhibitor I, Cell-permeable (Cat. No. 235423) in DMSO.
      Hill FormulaC₉₄H₁₅₈N₂₀O₂₇
      Chemical formulaC₉₄H₁₅₈N₂₀O₂₇
      Hygroscopic Hygroscopic
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcaspase-3
      Primary Target IC<sub>50</sub>200 pM inhibiting PARP cleavage in cultured human osteosarcoma cell extracts
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot, purge with inert gas, and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ Caspase-3 Inhibitor I, Cell-Permeable - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      235427

      Références bibliographiques

      Aperçu de la référence bibliographique
      Lin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305.
      Nicholson, D.W. 1996. Nature Biotechnol. 14, 297.
      Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
      Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
      Nicholson, D.W., et al. 1995. Nature 376, 37.
      Tewari, M., et al. 1995. Cell 81, 801.
      Lazebnik, Y.A., et al. 1994. Nature 371, 346.

      Brochure

      Titre
      Caspases and other Apoptosis Related Tools Brochure

      Citations

      Titre
    • Jurg Grunenfelder, et al. (2001) Upregulation of Bcl-2 through caspase-3 inhibition ameliorates ischemia/reperfusion injury in rat cardiac allografts. Circulation 104, I202-I206.
    • Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-March-2008 JSW
      SynonymsCell-permeable, DEVD-CHO; CPP32/Apopain Inhibitor, Cell-permeable
      DescriptionA cell-permeable inhibitor of caspase-3. The C-terminal DEVD-CHO sequence of this peptide is a highly specific, potent, and reversible inhibitor of caspase-3 (Ki <1 nM) that has also been shown to strongly inhibit PARP cleavage in cultured human osteosarcoma cell extracts (IC50 = 200 pM). The N-terminal sequence (residues 1-16) corresponds to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF) and confers cell-permeability to the peptide.
      FormLiquid
      FormulationA 5 mM (1 mg/100 µl) solution of Caspase-3 Inhibitor I, Cell-permeable (Cat. No. 235423) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₉₄H₁₅₈N₂₀O₂₇
      Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO
      Purity≥90% by HPLC
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot, purge with inert gas, and freeze (-20°C).
      Toxicity Irritant
      ReferencesLin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305.
      Nicholson, D.W. 1996. Nature Biotechnol. 14, 297.
      Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
      Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
      Nicholson, D.W., et al. 1995. Nature 376, 37.
      Tewari, M., et al. 1995. Cell 81, 801.
      Lazebnik, Y.A., et al. 1994. Nature 371, 346.
      Citation
    • Jurg Grunenfelder, et al. (2001) Upregulation of Bcl-2 through caspase-3 inhibition ameliorates ischemia/reperfusion injury in rat cardiac allografts. Circulation 104, I202-I206.