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559405 SB 225002 - CAS 182498-32-4 - Calbiochem

559405
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Empirical FormulaCAS #
C₁₃H₁₀BrN₃O₄ 182498-32-4

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559405-1MG
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      Description
      OverviewA potent, selective, and competitive antagonist of the G-protein coupled receptor CXCR2 (IL-8RB; IC50 = 22 nM for the inhibition of 125I-IL-8 binding to CXCR2). Shows ~150-fold selectivity over CXCR1. Inhibits human and rabbit neutrophil chemotaxis induced by both IL-8 and GROα in vitro and in vivo selectively blocks IL-8-induced neutrophil margination in rabbits. Reduces presenilin expression, inhibits γ-secretase activity, and blocks Aβ40/42 production and notch processing; further, demonstrates in vivo efficacy in mouse models.
      Catalogue Number559405
      Brand Family Calbiochem®
      SynonymsN-(2-Hydroxy-4-nitrophenyl)-Nʹ-(2-bromophenyl)urea, CXCR2 Antagonist II
      References
      ReferencesBakshi, P., et al. 2009. ACS Chem. Biol. in press.
      White, J.R., et al. 1998. J. Biol. Chem. 273, 10095.
      Product Information
      CAS number182498-32-4
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₃H₁₀BrN₃O₄
      Chemical formulaC₁₃H₁₀BrN₃O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCXCR2
      Primary Target IC<sub>50</sub>22 nM for the inhibition of 125I-IL-8 binding to CXCR2
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SB 225002 - CAS 182498-32-4 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      559405

      Références bibliographiques

      Aperçu de la référence bibliographique
      Bakshi, P., et al. 2009. ACS Chem. Biol. in press.
      White, J.R., et al. 1998. J. Biol. Chem. 273, 10095.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      SynonymsN-(2-Hydroxy-4-nitrophenyl)-Nʹ-(2-bromophenyl)urea, CXCR2 Antagonist II
      DescriptionA potent and selective antagonist of G-protein coupled receptor CXCR2 (IL-8RB; IC50 = 22 nM for the inhibition of 125I-IL-8 binding to CXCR2). Inhibits human and rabbit neutrophil chemotaxis induced by both IL-8 and GROα in vitro and selectively blocks IL-8-induced neutrophil margination in rabbits. Reduces presenilin expression, inhibits γ-secretase activity, and blocks Aβ40/42 production and notch processing; further, demonstrates in vivo efficacy in mouse models.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number182498-32-4
      Chemical formulaC₁₃H₁₀BrN₃O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (200 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBakshi, P., et al. 2009. ACS Chem. Biol. in press.
      White, J.R., et al. 1998. J. Biol. Chem. 273, 10095.