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Merck

401482

IKK-2 Inhibitor V

The IKK-2 Inhibitor V, also referenced under CAS 978-62-1, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

Synonym(s):

IKK-2 Inhibitor V, N-(3,5-Bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide, IMD-0354

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About This Item

Empirical Formula (Hill Notation):
C15H8ClF6NO2
CAS Number:
978-62-1
Molecular Weight:
383.67
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00218820

Product Name

IKK-2 Inhibitor V, The IKK-2 Inhibitor V, also referenced under CAS 978-62-1, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

SMILES string

FC(F)(F)c1cc(cc(c1)C(F)(F)F)NC(=O)c2c(ccc(c2)Cl)O

InChI

1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25)

InChI key

CHILCFMQWMQVAL-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

ethanol: 1 mg/mL
DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cell permeable: yes
Primary Target
IKK-2
Product does not compete with ATP.
Reversible: no
Target IC50: ~ 250 nM blocking IκBα phosphorylation

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable IKK-2 inhibitor that selectively blocks IκBα phosphorylation (IC50 ~250 nM) and prevents the induction of NF-κB p65 nuclear translocation. Reported to suppress neoplastic proliferation of mast cells with constitutively activated c-kit receptor. Shown to offer cardioprotection by reducing IL-1β and MCP-1 production (IC50<1 µM) in cardiomyocytes, and ameliorate insulin resistance in diabetic KKAy mice by regulating adiponectin release.
A cell-permeable salicylamide compound that acts as an IKK-2 inhibitor by selectively blocking IκBα phosphorylation (IC50 ~ 250 nM) and thereby prevents the induction of NF-κB p65 nuclear translocation. Shown to offer cardioprotection by reducing IL-1β and MCP-1 production (IC50<1 µM) in cardiomyocytes, and ameliorate insulin resistance in KKAy mice by regulating adiponectin release.

Other Notes

Kamon, J., et al. 2004. Biochem. Biophys. Res. Commun.323, 242.
Onai, Y., et al. 2004. Cardiovasc. Res.63, 51.
Tanaka, A., et al. 2004. Blood105, 2324.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

Certificates of Analysis (COA)

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