SML3589
ITD-1
≥98% (HPLC)
Synonym(s):
4-[1,1′-Biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-3-quinolinecarboxylic acid ethyl ester, Inducer of type II TGF-b receptor (TGFBR2) degradation-1
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About This Item
Empirical Formula (Hill Notation):
C27H29NO3
CAS Number:
Molecular Weight:
415.52
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
SMILES string
O=C(CC(C)(C)C1)C2=C1NC(C)=C(C(OCC)=O)C2C(C=C3)=CC=C3C4=CC=CC=C4
InChI
1S/C27H29NO3/c1-5-31-26(30)23-17(2)28-21-15-27(3,4)16-22(29)25(21)24(23)20-13-11-19(12-14-20)18-9-7-6-8-10-18/h6-14,24,28H,5,15-16H2,1-4H3
InChI key
ULFUJLFTRWWLPO-UHFFFAOYSA-N
Biochem/physiol Actions
ITD-1 is a selective TGF-ß pathway inhibitor that induces selective proteasomal degradation of type II TGF-b receptor (TGFBR2). ITD-1 stimulates embryonic stem cells to differentiate into cardiomyocytes.
Selective TGF-ß pathway inhibitor; stimulates ESC differentiation into cardiomyocytes
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Small molecule-mediated TGF-? type II receptor degradation promotes cardiomyogenesis in embryonic stem cells
Cell Stem Cell, 11, 242-252 (2012)