- Ag(I)-catalyzed aminofluorination of alkynes: efficient synthesis of 4-fluoroisoquinolines and 4-fluoropyrrolo[α]isoquinolines.
Ag(I)-catalyzed aminofluorination of alkynes: efficient synthesis of 4-fluoroisoquinolines and 4-fluoropyrrolo[α]isoquinolines.
Organic letters (2012-10-24)
Tao Xu, Guosheng Liu
PMID23088282
ABSTRACT
A silver-catalyzed intramolecular oxidative aminofluorination of alkynes has been developed by using NFSI as a fluorinating reagent. This reaction represents an efficient method for the synthesis of various 4-fluoroisoquinolines and 4-fluoropyrrolo[α]isoquinolines.
MATERIALS
Product Number
Brand
Product Description
Silver nitrate, puriss. p.a., ≥99.5% (AT)
Silver nitrate, meets analytical specification of Ph. Eur., BP, USP, 99.8-100.5%
Silver nitrate, BioXtra, >99% (titration)
Silver nitrate, ACS reagent, ≥99.0%
Silver nitrate, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.8%