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118500 ATM Kinase Inhibitor - CAS 587871-26-9 - Calbiochem

ATM Kinase Inhibitor, CAS 587871-26-9, is a cell-permeable, potent, ATP-competitive inhibitor of ATM Kinase (IC₅₀ = 13 nM; Ki = 2.2 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, KU 55933, KU55933, KU-55933

Primary Target: ATM Kinase
118500
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
587871-26-9C₂₁H₁₇NO₃S₂

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118500-2MG
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      Description
      OverviewA cell-permeable disubstituted pyranone compound that acts as a potent and ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM; Ki = 2.2 nM). Displays excellent selectivity over other PIKK family kinases (IC50 = 2.5 , 9.3 , 16.6 µM for DNA-PK, mTOR, PI 3-K, respectively; IC50 > 100 = µM for PI 4-K and ATR) and exhibits little activity towards a panel of 60 other kinases even at concentrations as high as 10 µM. Inhibits ATM-dependent cellular protein phosphorylation following ionizing radiation (IR) and sensitizes cells with wild-type ATM, but not mutant ATM, to the cytotoxic effects of IR and DNA-damaging agents. A 10 mM (2 mg/506 µl) solution of ATM Kinase Inhibitor (Cat. No. 118502) in DMSO is also available.
      Catalogue Number118500
      Brand Family Calbiochem®
      Synonyms2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, KU 55933, KU55933, KU-55933
      References
      ReferencesPereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
      Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
      Hickson, I., et al. 2004. Cancer Res. 64, 9152.
      Product Information
      CAS number587871-26-9
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₂₁H₁₇NO₃S₂
      Chemical formulaC₂₁H₁₇NO₃S₂
      HS Code2934 99 39
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetATM Kinase
      Primary Target IC<sub>50</sub>13 nM
      Primary Target K<sub>i</sub>2.2 nM for ATM kinase
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      118500-2MG 07790788047894

      Documentation

      ATM Kinase Inhibitor - CAS 587871-26-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      ATM Kinase Inhibitor - CAS 587871-26-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      118500

      References

      Reference overview
      Pereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
      Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
      Hickson, I., et al. 2004. Cancer Res. 64, 9152.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-February-2014 JSW
      Synonyms2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, KU 55933, KU55933, KU-55933
      DescriptionA cell-permeable disubstituted pyranone compound that acts as a potent and ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM; Ki = 2.2 nM). Displays excellent selectivity over other PIKK family kinases (IC50 = 2.5, 9.3, 16.6 µM for DNA-PK, mTOR, PI 3-K, respectively; IC50 > 100 µM for PI 4-K and ATR) and exhibits little activity towards a panel of 60 other kinases even at concentrations as high as 10 µM. Inhibits ATM-dependent cellular protein phosphorylation following ionizing radiation (IR) and sensitizes cells with wild-type ATM, but not mutant ATM, to the cytotoxic effects of IR and DNA-damaging agents.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number587871-26-9
      Chemical formulaC₂₁H₁₇NO₃S₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (4 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesPereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
      Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
      Hickson, I., et al. 2004. Cancer Res. 64, 9152.