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852008 Fmoc-Cys(Trt)-OH

Fmoc-Cys(Trt)-OH Novabiochem®. CAS 103213-32-7, molar mass 585.72 g/mol.

Fmoc-Cys(Trt)-OH MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 103213-32-7 Molar Mass: 585.73 g/mol Hill Formula: C₇H₃₁NO₄S
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Overview

Replacement Information

Key Spec Table

CAS #Hill FormulaMolar Mass
103213-32-7C₇H₃₁NO₄S585.73 g/mol

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      8520080100
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          Description
          Catalogue Number852008
          Replaces04-12-1018
          Brand Family Novabiochem®
          Alternate Names
          • N-α-Fmoc-S-trityl-L-cysteine
          Background InformationThe standard derivative for Fmoc SPPS of peptides containing Cys [1]. The Trt group is removed with 95% TFA containing 1-5% TIS. Ideally, this derivative should be introduced using the symmetrical anhydride or DIPCDI/HOBt activation [2,3] to minimize enantiomerization. If activation with uronium or phosphonium reagents, such as HBTU or PyBOP®, is to be employed, it is strongly recommended that collidine is used as the base [4], as this has been shown to significantly reduce loss of optical integrity during coupling.

          The product number for this product was previously 04-12-1018.

          To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
          References
          Product Information
          CAS number103213-32-7
          Hill FormulaC₇H₃₁NO₄S
          Molar Mass585.73 g/mol
          HS Code2930 90 19
          Structure formula ImageStructure formula Image
          Quality LevelMQ400
          Applications
          ApplicationFmoc-Cys(Trt)-OH Novabiochem®. CAS 103213-32-7, molar mass 585.72 g/mol.
          Biological Information
          Physicochemical Information
          Melting Point164 - 175 °C
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Storage class10 - 13 Other liquids and solids
          WGKWGK 3 highly hazardous to water
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          StorageStore at -15°C to -25°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Color (visual)white to off white
          Appearance of substance (visual)powder
          Color index (0,5 M in DMF)≤ 150 Hazen
          Identity (IR)passes test
          Enantiomeric purity≥ 99.5 % (a/a)
          Purity (HPLC)≥ 99.0 % (a/a)
          Fmoc-ß-Ala-OH (HPLC)≤ 0.1 % (a/a)
          Fmoc-ß-Ala-Cys (Trt) -OH (HPLC)≤ 0.1 % (a/a)
          Fmoc-Cys(Trt)-Cys(Trt)-OH (HPLC)≤ 0.1 % (a/a)
          Fmoc-Cys-OH (HPLC)≤ 0.1 % (a/a)
          Assay free amino acid (HPLC)≤ 0.2 %
          Purity (TLC(011A))≥ 98 %
          Purity (TLC(0811))≥ 98 %
          Solubility (1 mmole in 2 ml DMF)clearly soluble
          Assay (acidimetric)≥ 98.0 %
          Water (K. F.)≤ 2.0 %
          Ethyl acetate (HS-GC)≤ 0.5 %
          Acetate (IC)≤ 0.02 %
          For TLC-Systems see our General Catalog
          Global Trade Item Number
          Catalogue Number GTIN
          8520080025 04027269084783
          8520080100 04027269084790

          Documentation

          Fmoc-Cys(Trt)-OH SDS

          Title

          Safety Data Sheet (SDS) 

          Citations

          Title
          • [1] S. N. McCurdy (1989) Pept. Res., 2, 147.
          • [2] T. Kaiser, et al. (1996) Tetrahedron Lett., 37, 1187.
          • [3] Y. X. Han, et al. (1997) J. Org. Chem., 62, 4307.
          • [4] Y. N. Angell (2002) J. Peptide Res., 5, 292.