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852050 Fmoc-Trp(Boc)-OH

Fmoc-Trp(Boc)-OH Novabiochem®. CAS 143824-78-6, molar mass 526.59 g/mol.

Fmoc-Trp(Boc)-OH MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 143824-78-6 Molar Mass: 526.59 g/mol Hill Formula: C₃₁H₃₀N₂O₆
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852050
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Overview

Replacement Information

Key Spec Table

CAS #Hill FormulaMolar Mass
143824-78-6C₃₁H₃₀N₂O₆526.59 g/mol

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      8520500100
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          Description
          Catalogue Number852050
          Replaces04-12-1103
          Brand Family Novabiochem®
          Alternate Names
          • N-α-Fmoc-N-in-t.-Boc-L-tryptophan
          Background InformationThe use of this N-in-Boc protected derivative overcomes most of the problems associated with the preparation of Trp containing-peptides by Fmoc SPPS [1]. Cleavage with TFA generates an N-in-carboxy indole which protects the Trp from alkylation [1, 2, 3] and sulfonation [1, 4, 5, 6, 7]. The N-in-carboxy group is removed under aqueous conditions during normal work-up of the peptide.



          The product number for this product was previously 04-12-1103.

          To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
          References
          Product Information
          CAS number143824-78-6
          Hill FormulaC₃₁H₃₀N₂O₆
          Molar Mass526.59 g/mol
          HS Code2933 99 49
          Structure formula ImageStructure formula Image
          Quality LevelMQ300
          Applications
          ApplicationFmoc-Trp(Boc)-OH Novabiochem®. CAS 143824-78-6, molar mass 526.59 g/mol.
          Biological Information
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Storage class10 - 13 Other liquids and solids
          WGKWGK 3 highly hazardous to water
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          StorageStore at -15°C to -25°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Color (visual)white to off white
          Appearance of substance (visual)powder
          Color index (0,5 M in DMF)≤ 150 Hazen
          Identity (IR)passes test
          Enantiomeric purity≥ 99.7 % (a/a)
          Purity (HPLC)≥ 97.5 % (a/a)
          Fmoc-ß-Ala-OH (HPLC)≤ 0.3 % (a/a)
          Fmoc-ß-Ala-Trp (Boc)-OH (HPLC)≤ 0.1 % (a/a)
          Fmoc-Trp(Boc)-Trp(Boc)-OH (HPLC)≤ 0.1 % (a/a)
          Fmoc-Trp-OH (HPLC)≤ 1.0 % (a/a)
          Assay free amino acid (HPLC)≤ 0.2 %
          Solubility (25 mmole in 50 ml DMF)clear soluble
          Purity (TLC(011A))≥ 98 %
          Purity (TLC(0811))≥ 98 %
          Assay (acidimetric)≥ 90.0 %
          Water (K. F.)≤ 2.0 %
          Ethyl acetate (HS-GC)≤ 2.5 %
          Acetate (IC)≤ 0.10 %
          For TLC-Systems see our General Catalog
          Global Trade Item Number
          Catalogue Number GTIN
          8520500025 04027269087234
          8520500100 04027269087241

          Documentation

          Fmoc-Trp(Boc)-OH SDS

          Title

          Safety Data Sheet (SDS) 

          Citations

          Title
          • [1] P. White in 'Peptides, Chemistry & Biology, Proc. 12th American Peptide Symposium', J. A. Smith & J. E. Rivier (Eds), ESCOM, Leiden, 1992, pp. 537.
          • [2] B. Riniker, et al. (1993) Tetrahedron, 49, 9307.
          • [3] T. Johnson, et al. (1993) J. Chem. Soc., Chem. Commun., 369.
          • [4] H. Choi, et al. (1993) Int. J. Peptide Protein Res., 42, 58.
          • [5] C. G. Fields, et al. (1993) Tetrahedron Lett., 34, 6661.
          • [6] T. Lescrinier, et al. (1995) Lett. Pept. Sci., 2, 225.
          • [7] M. Noda & M. Kiffe (1997) J. Peptide Res., 50, 329.