Millipore Sigma Vibrant Logo

855029 N-Cyclohexylcarbodiimide,N'-methyl polystyrene

Novabiochem®

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 9003-70-7
View Products on Sigmaaldrich.com
855029
View Pricing & Availability

Overview

Replacement Information

Key Spec Table

CAS #
9003-70-7

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
8550290005
Retrieving availability...
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Plastic bottle 5 g
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      Description
      Catalogue Number855029
      Replaces01-64-0211
      Brand Family Novabiochem®
      Background InformationN-Cyclohexylcarbodiimide,N'-methyl polystyrene [1] is an ideal tool for mediating solution phase coupling reactions. Typically, the amine and carboxylic acid are treated with a 2-3 fold excess of resin in DCM or DMF [2, 3]; a slight excess of carboxyl component over amine component is often used to help drive the reaction to completion. As excess acid and urea by-products remain attached to the resin at the end of the reaction, the product can normally be isolated pure by filtration and evaporation of the reaction mixture. Reactions can be accelerated by the addition of auxiliary nucleophiles such as HOBt; these can be removed using polyamine- or TBD-polystyrene. This resin has also been used in conjunction with DMAP to mediate ester formation [4].

      The product number for this product was previously 01-64-0211.

      To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
      References
      Product Information
      CAS number9003-70-7
      HS Code3903 90 90
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      Biological Information
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Storage class10 - 13 Other liquids and solids
      WGKWGK 1 slightly hazardous to water
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      StorageStore at +2°C to +8°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Color (visual)slightly beige to brown
      Appearance of substance (visual)beads
      Loading (determined by HPLC after reaction of Z-Phe-OH with cyclohexylamine)≥ 1.3 mmol/g
      Swelling Volume (in CH₂Cl₂)lot specific result
      The polymer matrix is copoly (styrene-2 % DVB), 200 - 400 mesh.
      Global Trade Item Number
      Catalogue Number GTIN
      8550290005 04027269110475

      Documentation

      N-Cyclohexylcarbodiimide,N'-methyl polystyrene SDS

      Title

      Safety Data Sheet (SDS) 

      Citations

      Title
      • [1] G.M Weinshenker, et al. (1988) Org. Synth., Coll. Vol. VI, 951.
      • [2] Y. Guan, et al. (2000) J. Comb. Chem., 2, 297.
      • [3] K. Senton, et al. (2003) J. Comb. Chem., 5, 336.
      • [4] M. Cano, et al. (2002) J. Org. Chem., 67, 129.